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All Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Mohammad M. Al-Tufah
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Health Professions Nursing Public Health

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Microwave-Assisted Synthesis and Antibacterial–Anticancer Evaluation of Sulfadiazine-Imine Derivatives Dhamer Ismael Madab; Mohammad M. Al-Tufah; Diaa M. Najim
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1366

Abstract

This study synthesized novel sulfadiazine-imine derivatives (A1 and A2) using a microwave-assisted method by reacting sulfadiazine with orsellinaldehyde and 2-hydroxy-5-methylbenzaldehyde. The synthesis involved the nucleophilic addition of sulfadiazine to the aldehyde groups, forming imine bonds efficiently under microwave irradiation within 15 minutes. The antibacterial efficacy of the synthesized derivatives was tested against Bacillus subtilis, Streptococcus pneumoniae, and Escherichia coli using agar well diffusion methods. The derivatives A1 and A2 exhibited significantly improved antibacterial activities compared to sulfadiazine, with A1 showing the highest efficacy. Specifically, inhibition zones for Bacillus subtilis reached 26 mm (A1 at 100 mg/mL) compared to 20 mm for sulfadiazine, and similar trends were observed against E. coli and S. pneumoniae. Furthermore, the cytotoxic activity against MCF-7 breast cancer cells revealed that both derivatives demonstrated dose-dependent cytotoxicity. For derivative A1, cell viability decreased to 19% at 320 ppm with an estimated IC50 between 40 and 80 ppm. Derivative A2 showed comparable cytotoxic behavior, with cell viability dropping to 12.6% at the highest concentration tested. The enhanced antibacterial and anticancer properties are attributed to increased lipophilicity and improved cellular penetration conferred by the imine functional group. This research highlights the potential of microwave-assisted derivatization of sulfadiazine to produce compounds with promising therapeutic applications.
Synthesis of Vanadium Pentoxide (V₂O₅) by Green Method Using Olive Oil as A Reducing Agent and Study of its Physical Properties Saleh Yaseen, Ahmed; Yosef Othman Homeda; Mohammad M. Al-Tufah; Mutlak Saud Khalaf; Mohannd Faisal Shareef
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1943

Abstract

This study reports the green synthesis of vanadium pentoxide (V₂O₅) using virgin olive oil as a natural and environmentally benign reducing agent. The approach aims to minimize the environmental impacts associated with conventional synthesis routes. Structural and physicochemical characterizations confirmed the successful formation of nanoscale V₂O₅. X‑ray diffraction (XRD) analysis indicated an average crystallite size of approximately 16.57 nm, evidencing high crystallinity. Fourier‑transform infrared spectroscopy (FTIR) revealed characteristic V=O and V–O–V vibrations with bands associated with physisorbed water, confirming the correct oxide framework. Field‑emission scanning electron microscopy (FE‑SEM) showed irregularly shaped nanoparticles with a representative particle diameter of ~32.62 nm. Brunauer–Emmett–Teller (BET) and Barrett–Joyner–Halenda (BJH) analyses yielded a specific surface area of 10.817 m²/g, a total pore volume of 0.024277 cm³/g, and a broad mesoporous distribution (20–90 nm). Energy‑dispersive X‑ray spectroscopy (EDX) confirmed the purity of V₂O₅ with weight fractions of V (69.40%) and O (30.60%), consistent with the stoichiometric composition. Overall, the results demonstrate the effectiveness of olive oil as a green reducing agent for preparing nanoscale V₂O₅, which is promising for catalysis, energy storage, sensors, and clean‑energy applications.
Co-Authors Dhamer Ismael Madab Diaa M. Najim Mohannd Faisal Shareef Mutlak Saud Khalaf Saleh Yaseen, Ahmed Yosef Othman Homeda