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All Journal Bali Dermatology Venereology and Aesthetic Journal The International Journal of Medical Science and Health Research
Desak Nyoman Trisepti Utami
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The role of anti-phenolic glycolipid-1 serological test in leprosy Ni Luh Putu Ratih Vibriyanti Karna; Anak Agung Indah Jayanthi; Desak Nyoman Trisepti Utami
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 1 (June 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/3zcf9307

Abstract

The number of new leprosy cases in the world is surprisingly high, Indonesia is still at the third rank in the term of new leprosy cases over the world. Leprosy control strategies can be successful if early diagnosis and appropriate therapy are carried out. Currently, several serological tests have been developed which can help detecting subclinical leprosy, making the diagnosis,and monitoring therapy. One such serological tests is the anti-Phenolic Glycolipid-1 (PGL-1) serological test. The antibody response to PGl-1 is mainly IgM, the amount of this antibody is correlated to the number of bacteria; so, the titer is higher in lepromatous type compared with tuberculoid type, this causes serological tests still have limitation in diagnosing leprosy, especially in paucibacillary type leprosy.
Effectiveness of Rosmarinus officinalis for Androgenetic Alopecia: A Literature Review Cintantya Prakasita; Desak Nyoman Trisepti Utami; Natasha Caroline Gigir; Ni Ketut Putri Ratih Sindunata
The International Journal of Medical Science and Health Research Vol. 21 No. 2 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/khjhbh24

Abstract

Androgenetic alopecia (AGA), also known as androgenic alopecia or male pattern baldness, is the most common type of progressive hair loss.. Androgenetic alopecia is hereditary and is transmitted through an autosomal dominant genetic pattern. This genetic predisposition is directly associated with androgen hormones, in which androgens induce miniaturization of hair follicles on the scalp and a progressive shortening of the anagen phase in the hair cycle. There are evidence-based therapeutic interventions for androgenetic alopecia, including both pharmacological and non-pharmacological approaches. The 5α-reductase inhibitors, finasteride and dutasteride, effectively suppress dihydrotestosterone (DHT) synthesis but are associated with sexual dysfunction including erectile dysfunction, reduced libido, and ejaculatory disorder as well as gynecomastia. Androgen receptor antagonists such as spironolactone may induce postural hypotension and hyperkalemia, cyproterone acetate carries risks of mood disturbances and hepatotoxicity, and flutamide is linked to dose-dependent severe hepatic injury. This literature review explores the therapeutic potential of herbal remedies Rosmarinus Officinalis known for their anti inflammatory agent, anti androgenic agent, anti fungal agent, photoprotective agent, and a vasodilator. This review emphasizes the potential and effectiveness of Rosmarinus Officinalis  in advancing dermatological care and providing effective, plant-based solutions for Androgenetic Alopecia with minimal side effects.
Co-Authors Anak Agung Indah Jayanthi Cintantya Prakasita Natasha Caroline Gigir Ni Ketut Putri Ratih Sindunata Ni Luh Putu Ratih Vibriyanti Karna