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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Mislamah, Mislamah
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Medicine & Pharmacology

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ANTIDIABETES DAN PROFIL HISTOPATOLOGI SEL BETA PANKREAS PADA MENCIT MODEL INDUKSI STREPTOZOTOSIN EKSTRAK ETANOL DAUN RENGGAK (Amomum dealbatum L.) Mislamah; Mislamah, Mislamah; Amalia, Ananda Ayu Amalia; Firma, Firma Amelia Kusuma; Abdul, Abdul Rahman Wahid; Safwan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2131

Abstract

antidiabetic effects because their flavonoid levels are higher than the fruit. This study aims to determine the antidiabetic activity of ethanol extract of renggak leaves (EEDR), the optimal dose and the histopathological profile of the mouse pankreas. To determine its antidiabetic activity, a pre-test (initial blood sugar level before STZ induction) and post-test (after STZ induction) were carried out on the blood sugar levels of mice. A total of 36 male white mice were divided into 6 groups, namely normal group, negative group (Na-CMC 0.5%), positive group (Metformin 500 mg), EEDR group at doses of 240, 300, and 360 mg/kgBW.. Test results LSD posthoc showed that there was a mean difference between treatment groups with significant antidiabetic activity (p value <0.05). The ethanol extract group of renggak leaves was dosed at 240 mg/kgBW. The histopathological profile of the pankreas in each group showed extensive necrosis, the islets of Langerhans and inch tubules were difficult to distinguish, the cells looked degenerative with incomplete cytoplasm and degenerative nuclei.
Co-Authors Abdul, Abdul Rahman Wahid Amalia, Ananda Ayu Amalia Firma, Firma Amelia Kusuma mislamah Safwan