This study aims to determine the influence of leadership, motivation, competence and work culture variables on the performance of teachers at SMKN 2 Sukoharjo. This study uses a quantitative descriptive approach. In this quantitative descriptive study, the author focuses on the research. The study took six months starting from observation to the preparation of data results and research conclusions, located at SMKN 2 Sukoharjo, Jl Solo-Wonogiri, Begajah, Sukoharjo, Central Java. The population of this study was 111 teachers at SMKN 2 Sukoharjo. The sampling technique in this study used saturated sampling (census), namely a sample collection technique using all samples in the existing population, namely 111 teachers. The variables used in this study include the dependent variable (Y) and the independent variable (X). The dependent variable (Y) is performance and the independent variable (X) contains four variables, namely leadership, motivation, competence and work culture. The data in this study were processed using multiple linear regression tools. The data collection method used a questionnaire. Data analysis using multiple regression analysis, t-test and F-test. Based on the results of the t-test, it shows that leadership, competence and work culture have a positive and significant effect on the performance of teachers at SMKN 2 Sukoharjo, while the motivation variable does not affect the performance of teachers at SMKN 2 Sukoharjo.