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All Journal Heart Science Journal Cermin Dunia Kedokteran
Wangsaputra, Vincent Kharisma
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology

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Tata Laksana Terkini Dermatitis Atopik Sedang dan Berat: Dari Patogenesis hingga Terobosan Tata Laksana. Putra, Muhammad Alifian Remifta; Wangsaputra, Vincent Kharisma; Penantian, Raya Makarim
Cermin Dunia Kedokteran Vol 51 No 7 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i7.1096

Abstract

Atopic dermatitis (AD), characterized by recurrent eczematous lesions and pruritus, is a major contributor to the total global burden of disability. The common management practice includes patient education and topical emollients and is heavily reliant on the use of anti-inflammatory agents with systemic corticosteroids. Monoclonal antibodies provide a novel, targeted approach towards specific cytokines. This study aims to highlight the novel systemic therapeutic drug aimed at specific targets. A comprehensive literature review utilizes databases including EMBASE, EBSCOhost, PubMed, Scopus, and Wiley Online Library, using keywords: “monoclonal antibody” AND “therapy” AND “atopic dermatitis”. Relevant papers containing different updates in atopic dermatitis management and the utilization of monoclonal antibodies are included in this review. The current regimen of monoclonal antibodies offers better management of moderate-to-severe AD. Monoclonal antibodies have become a promising therapy as they demonstrate better therapeutic effects in terms of skin barrier protection and anti-inflammatory and pruritusreducing effects. However, its application still faces various challenges such as side effects and infections. The heterogeneity and relapsing nature also add to the complexity and risk profile of AD management.
Unrecognized major aortopulmonary collateral arteries in double outlet right ventricle-ventricular septal defect: A rare case report Siagian, Sisca Natalia; Panjaitan, Elsa Hedia; Wangsaputra, Vincent Kharisma
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.17

Abstract

BACKGROUND: Major aortopulmonary collateral arteries (MAPCAs) are aberrant vessels that typically form to compensate for cyanotic congenital heart disease (CHD) with restricted pulmonary blood flow. This often obscures clinical suspicion of MAPCAs in CHDs associ-ated with pulmonary overcirculation, making it potentially unrecognized. CASE ILLUSTRATION: We report the case of a 5-month-old girl presenting with dyspnea, recurrent respiratory infections, and failure to thrive. Echocardiography revealed double outlet right ventricle (DORV) with ventricular septal defect (VSD) and patent ductus arteriosus (PDA). After initial treatment for heart failure and pneumonia, she underwent pul-monary artery (PA) banding and PDA ligation. Ongoing poor postoperative status prompted a second surgery, where intraventricular tunnel repair failed due to inability to wean from cardiopulmonary bypass. An atrial septectomy and PA band retightening achieved hemodynamic improvement, but the patient remained ventilator-dependent with recurrent pneumonia. Further evaluation with multislice CT and catheterisation uncovered previously undiagnosed MAPCAs supplying the right lung and a hypoplastic right pulmonary artery (RPA), precluding embolisation. Since the MAPCAs and hypoplastic RPA were initially unrecognized, the PA banding procedure inadvertently exacerbated the right lung. CONCLUSION: This case highlights the importance of considering MAPCAs in various CHD morphologies and emphasizes the value of pre-procedural imaging selection to optimize surgical planning and outcomes.
Co-Authors Panjaitan, Elsa Hedia Penantian, Raya Makarim Putra, Muhammad Alifian Remifta Sisca Natalia Siagian