Damanik, Lucky Pestauli
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Model Prediksi Preeklampsia di Daerah dengan Sumber Daya Rendah: Tinjauan Sistematik Damanik, Lucky Pestauli
Cermin Dunia Kedokteran Vol 51 No 9 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i9.1102

Abstract

The mechanism of preeclampsia is still unknown, so early diagnosis and termination of pregnancy are definitive therapies. A prediction model to be implemented in a low-resource setting is needed to predict the risk of pre-eclampsia in pregnant women. Pre-eclampsia prediction models also play a role in clinical decision-making, assisting with information, education, and communication (IEC) and considering the administration of aspirin prophylaxis. This study aims to systematically review the development of pre-eclampsia prediction models in a low-resource setting. PubMed, ScienceDirect, and Wiley Online Library databases between January 2019 and June 2023 were systematically reviewed. Article identification, screening, and selection of relevant articles, as well as data extraction, were carried out independently by the authors following PRISMA guidelines. Of the six articles that met the requirements, models that used maternal characteristics, risk factors, and physical examination. Laboratory tests improved the accuracy of pre-eclampsia prediction models in a low-resource setting. Examination with Doppler ultrasound and biomarkers could significantly improve the sensitivity and specificity of prediction models but could not be universally applied in a low-resource setting.
Transplantasi Uterus untuk Mengatasi Absolute Uterine Factor Infertility (AUFI) pada Sindrom Mayer-Rokitansky-Küster-Hauser (MRKH) Damanik, Lucky Pestauli
Cermin Dunia Kedokteran Vol 51 No 7 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i7.1148

Abstract

Infertility caused by the absence of the uterus or its physiological capabilities is called absolute uterine factor infertility (AUFI). One of the causes of AUFI is Mayer-Rokitansky-Küster-Hauser syndrome (MRKH), a congenital abnormality that results in the absence of or failure to develop a uterus, without any interference of secondary sex characteristics. The only proven therapy to overcome infertility in RMKH syndrome is uterine transplantation. However, there are ethical problems with the uterus transplant procedure, especially regarding the nature of the syndrome, which is not a life-saving intervention but is limited to life-enhancing purposes.