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Rahmad, David Denada
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Health Professions

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Limfadenopati Tuberkulosis dengan Drugs-induced Hepatitis (DIH) di Sikka, Nusa Tenggara Timur, Indonesia Rahmad, David Denada; Purnama, Asep
Cermin Dunia Kedokteran Vol 51 No 1 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i1.1181

Abstract

Background: The most common extrapulmonary TB is lymph node TB in 35% cases of worldwide. Drug-induced hepatitis (DIH) is the possible adverse effect of antimycobacterial agents. Case: An 18-year-old male with multiple tender lumps on the right side of his neck for the last 2 weeks. Physical findings were multiple masses in the right anterior supraclavicular and submandibular region. Biopsy revealed suppurative granulomatous lymphadenitis. The diagnosis is TB lymphadenitis and the first regimen of anti-TB was given, but the patient developed nausea and vomiting and increased AST/ALT after 5 days. Anti-TB was temporarily discontinued. Anti-TB regimen was resumed after clinical and laboratory returned to normal. Conclusion: Patients with TB and DIH need to be treated individually depending on their tolerance to the drugs. Careful clinical and laboratory monitoring was needed to prevent adverse effects and for best results.
Co-Authors Asep Purnama, Asep