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All Journal Cermin Dunia Kedokteran
Kristiawan, Febrilian
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Health Professions

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Potensi Citicoline dalam Menghambat Penurunan Fungsi Kognitif pada Gangguan Kognitif Ringan: Laporan Kasus Berbasis Bukti Wiyarta, Elvan; Kristiawan, Febrilian; Sinaga, Gideon Hot Partogi
Cermin Dunia Kedokteran Vol 51 No 8 (2024): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i8.1210

Abstract

Background: Citicoline has been associated with the improvement of various neurological conditions. This article aims to explore the potential of citicoline in preventing cognitive decline in mild cognitive impairment (MCI). Methods: A comprehensive literature search was conducted through 10 databases. Studies selected should include adult with cognitive impairment using citicoline. Articles were selected according to specified inclusion and exclusion criteria. A critical review and Level of Evidence assessment is done. Results: From a total of 265 studies obtained, 15 were selected and analyzed. The results show that citicoline has the potential to prevent cognitive decline, in patients with MCI, Alzheimer’s disease, Parkinson’s disease, ischemic stroke, and also in healthy individuals. Although results were varied, citicoline has consistently shown significant improvements in Mini-Mental State Examination (MMSE) scores and other cognitive tests. Conclusion: Citicoline has a potential in preventing cognitive decline in MCI. More research is needed to understand its long-term effects and mechanism of action.
Co-Authors Sinaga, Gideon Hot Partogi Wiyarta, Elvan