Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Journal of Islamic Pharmacy
Al-Rufaie, Mohauman Mohammad Majeed
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
EVOLUTION AND EFFECTIVENESS OF COLORMETRIC APPROACH FOR INVESTIGATION OF CEFTRIAXONE MEDICINE AS IN PURE FORM AND IN FORMULATION VIALS Al-Rufaie, Mohauman Mohammad Majeed
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6099

Abstract

A third-generation cephalosporin antibiotic was aceftriaxone medicine. Similar another (3rd generation cephalosporins), it has wide broad spectrum effectiveness versus gram positive as well as gram negative bacteria. Diverse approachs for analyses of the studied medicine are obtainable but are costly additionally time consumption. Therefor we have sophisticated developed novel, easy, simple as well as accurate colormetric approach for investigation of ceftriaxone medicine as pure form as well as in formulation vials by depending on  a specific color-generated reaction. This reaction involves the Schiff 's base formation reaction between ceftriaxone drug  with alcoholic 4- di ethyl amino benzaldehyde  (DEAB) reagent to produce a new ligand that reacts with cobalt (II) ion with heating to (50°C) in acidic media to form green colored complex exhibiting λmax at 496 nm. The medicine conformed with the Beer’s law with the linearity was observed between (2 –52) μg/ml additionally that  correlation coefficient was 0.9992 .The analyses outcomes were supported with LOD, LOQ, accuracy, recovery studies, ruggedness as well as precision. The approach was establish to be robust as well as economical.
ESTIMATION OF CEPHALOSPORINS (CEFTRIAXONE, CEFTAZIDIME) ANTIBIOTICS AS PURE AND PHARMACEUTIC FORMS BY COLOR PRODUCED REACTION IN UV-VIS SPECTROPHOTOMETIC TECHNIQUE Al-Rufaie, Mohauman Mohammad Majeed; Motaweq, Zahraa Yosif
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6098

Abstract

A new simple, accurate and low cost-effective UV-VIS spectrophotometric methods has been developed for the analysis of chosen cephalosporins (ceftriaxone, ceftazidime) in bulk samples and pharmaceutical dosage forms by using a specific  color-generated reaction. This method involves the Schiff 's base formation reaction between selected cephalosporins with alcoholic 5-sulfo salicylaldehyde reagent 5SSA with heating to establish a yellow colored product displaying λmax at 426 nm as well as 412 nm sequentially. These methods applied to the Beer’s law through the range of concentration was  (4 - 60 µg.ml-1), (5 -50µg ml-1) respectively for two drugs. The analysis results for these studies  have been tested statistically by the studies of recovery. These methods were successfully applied to the determination of the cephalosporins in bulk form and in Pharmaceuticals additionally it was shown that these methods have equivalent accuracy with the common method(BP)estimation procedures for the studied  drugs. The interferences from frequently taken excipients were  no influence on the estimation process .The study could discover a good  as an employment cost-influence and speed method which that possibility used for making quality control for  these cephalosporin antibiotics.
Co-Authors Motaweq, Zahraa Yosif