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All Journal Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Dental Medicine
Balqis, Noor Faizah
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Dentistry

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The role of continuous moderate-intensity exercise on increasing collagen density after tooth extraction Irmawati, Anis; Melinda, Nadya; Tantiana; Azzaim, Yassir Ahmad; Balqis, Noor Faizah; Al-Tayar, Baher
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 1 (2024): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i1.p38-44

Abstract

Background: The wound healing process post-extraction is expected to be quick, which can reduce the risk of complications and restore normal tissue function. A minimum oxygen supply needs to be met so that acceleration of the wound healing process can occur. Wound healing can be accelerated by continuous moderate-intensity exercise with increasing tissue oxygenation. Collagen requires oxygen in the procollagen formation process to support wound healing. Purpose: This study aimed to prove the role of continuous moderate-intensity exercise in increasing collagen density in the dental sockets of Wistar rats (Rattus norvegicus) after tooth extraction. Methods: Four groups of Wistar rats were created: control groups K1 (on day 3) and K2 (on day 7), and treatment groups K3 (on day 3) and K4 (on day 7). K1 and K2 were submerged in a bucket of water, and K3 and K4 received daily moderate-intensity exercise for a duration of two weeks. The rats' incisors were extracted on the day 15. Post-extraction collagen density was measured on day 3 (K1 and K3) and on day 7 (K2 and K4). The one-way ANOVA test and post-hoc Tukey test were used in the statistical analysis of the data. Results: There was a significant difference between all groups (p: 0.0001; p<0.05). Group K4 had a higher collagen density than the other groups. Conclusion: Continuous moderate-intensity exercise played a role in increasing the density of collagen in the rat tooth socket after tooth extraction.
Antibacterial potential of robusta coffee beans (Coffea canephora var. robusta): A review Irmawati, Anis; Nurmalia, Salsabila; Rahmaputri, Annisa; Mahmudati, Nurul; Noman, Labib; Balqis, Noor Faizah
Indonesian Journal of Dental Medicine Vol. 9 No. 1 (2026): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v9i1.2026.48-55

Abstract

Background: A gram-positive bacterium, Staphylococcus aureus, is known for causing infections in areas like the skin, lungs, and mouth, and has spurred interest in natural remedies due to growing antibiotic resistance. This has led researchers to explore alternatives from sources such as Robusta coffee beans (Coffea canephora var. robusta), which contain potent bioactive substances. Purpose: The review aims to elaborate on the effectiveness of Robusta coffee beans in combating pathogens like S. aureus and to pinpoint the key ingredients contributing to their antibacterial activity. Reviews: Research indicates that Robusta coffee beans are rich in active elements (caffeine, chlorogenic acid, caffeic acid, and trigonelline), all of which demonstrate antimicrobial and antivirulence capabilities. These compounds work by compromising the integrity of the bacterial cell membrane, blocking protein production, and weakening the cell wall, ultimately resulting in cell breakdown. Chlorogenic acid, the most abundant of these, shows both inhibitory and lethal effects on bacteria. S. aureus is notorious for building tolerance to multiple antibiotics, complicating treatment. This challenge stems from its harmful traits, notably Panton-Valentine Leukocidin (PVL), which boosts its danger by destroying leukocytes and triggering tissue necrosis. Conclusion: Robusta coffee beans (C. canephora var. robusta) have great potential antibacterial activity attributed to their bioactive compounds, which inhibit pathogens such as S. aureus, Escherichia coli, Staphylococcus epidermidis, and Salmonella typhi. These findings suggest that robusta coffee beans may serve as a viable source for developing alternative natural antibacterial formulations, particularly against S. aureus associated infections.
Co-Authors Al-Tayar, Baher Anis Irmawati Azzaim, Yassir Ahmad Melinda, Nadya Noman, Labib Nurmalia, Salsabila Nurul Mahmudati Rahmaputri, Annisa Tantiana