<![CDATA[Presbycusis is an age-related hearing loss caused by a degeneration process which is a cumulative effect of various risk factors. Hearing Handicap Inventory for the Elderly-Screening version (HHIE-S) questionnaire is a questionnaire that can be used to measure the quality of life in patients with hearing loss. This study aimed to determine the relationship between presbycusis with the quality of life. The research uses cross sectional analytical research methods. The data used in form of primary data is the result of filling in the guided questionnaire and the results of the audiogram, while secondary data is in the form of medical records of presbycusis patients at Dustira Hospital in the period January 2017-December 2018. Data were analyzed by Chi-Square and Spearman Correlation Test. The incidence of presbycusis in the period January 2017-December 2018 at Dustira Hospital was 2,6%. The result showed most of the patients were 65-74 years old (61,8%), male (52,7%), married (58,2%), economic were similar between moderate and low economic status (49.1%), had a history of chronic diseases (76, 4%), had a moderate degree of hearing loss (61,8%) and had a mild-moderate degree of quality of life (52,7%). Based on HHIE-S questionnaire the results showed that there was a significant and strong relationship between presbycusis and patients’ quality of life (p <0.001) and r=0,509. In conclusion, degrees of hearing loss in presbycusis patients will correspond to degrees of decrease in quality of life. DOI : 10.35990/amhs.v1n2.p54-63 REFERENCES Kementerian Kesehatan Republik Indonesia. Gambaran kesehatan lanjut usia di Indonesia. Buletin Jendela Data dan Informasi Kesehatan: Kementerian Kesehatan RI; 2013: 27-39. Suhartin P. Teori penuaan, perubahan pada sistem tubuh dan implikasinya pada lansia. Semarang: Fakultas Kedokteran Universitas Diponegoro; 2010. 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