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Dwi Astuti, Elsa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulasi Ekstrak Siwak (Salvadora persica) Sebagai Mouth Spray dan Uji Efektivitas Terhadap Bakteri Staphylococcus aureus Nugraha, Nasywa Fatihah Bintang; Fauzi, Ahmad; Dwi Astuti, Elsa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1133

Abstract

Mouth-related problems often occur in human life, one of which is bad breath. Mouth spray is a health product that contains a combination of active ingredients and additional ingredients such as antibacterial, freshener, or moisturizer that work to support dental and oral health. Miswak (Salvadora persica) contains large amounts of chloride, fluorine, trimethylamine and resin, silica sulfur and vitamin C, where these chemical ingredients have great benefits for dental and oral health. This study aims to formulate miswak extract in the form of a mouth spray preparation and test its effectiveness against Staphylococcus aureus bacteria and use Simple Lattice Design as an optimization method. Extraction was carried out by the maceration method using 96% ethanol, then the extract was formulated in the form of a mouth spray preparation. The physical properties of the mouth spray were evaluated through organoleptic tests, pH, clarity and viscosity, while the antibacterial activity test was carried out by the well diffusion method. The results of the organoleptic test showed that all formulas had a dark brown color and a distinctive odor. The results of the clarity test for the five formulas looked clear and there were no visible particles. The pH test showed that all formulas had pH results within the safe range. The viscosity test did not meet the requirements, with an average result of 11.43 ± 0.52 cP. The antibacterial test showed that the miswak extract had antibacterial activity with an inhibition zone diameter of 16.25 mm against Staphylococcus aureus bacteria.
Formulasi Sediaan Denture Cleanser Dengan Ekstrak Siwak (Salvadora persica) Dan Uji Efektivitas Terhadap Bakteri Staphylococcus aureus Dwi Astuti, Elsa; Fauzi, Ahmad; Fatihah Bintang Nugraha , Naywa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1134

Abstract

Plaque buildup and bacterial accumulation on the surface of dentures are common problems faced by denture users. One alternative that can be used to clean dentures is miswak (Salvadora persica). Miswak contains many natural ingredients, including sodium chloride, potassium chloride, salvadourea, oleic acid, linoleic acid, trimethylamine, thiocyanate, benzyl isothiocyanate, and nitrate, silica, vitamin C, resin, tannin, saponin, N-benzyl-2 phenylacetamide, lignan, flavonoid, fluoride, calcium, sodium bicarbonate, and salvadorin. The purpose of this study was to formulate an effective denture cleanser from miswak extract using the Simplex Lattice Design (SLD) optimization method and to test its effectiveness against Staphylococcus aureus bacteria. The method used for the extraction process was the maceration method using 96% alcohol. For the antibacterial test of the denture cleanser preparation, the time kill assay method was used. The physical properties of the denture cleanser preparations were tested including organoleptic tests, clarity tests, pH tests, and viscosity tests. The results of the physical properties of the preparations in the organoleptic test for formulas 1 to 5 showed the characteristics of mint odor, brown color, and liquid form. The clarity test for all five formulas showed clear results and also no foreign particles and was declared to have met the requirements. The pH test results for the five formulas ranged from 6.28 ± 0.01 to 6.43 ± 0.01 and had met the requirements. The viscosity test did not meet the requirements because the results ranged from 10 ± 2 to 12.67 ± 1.15. The antibacterial test showed that there was no significant difference between all test groups regarding antibacterial activity.
Co-Authors Fatihah Bintang Nugraha , Naywa Fauzi Ahmad Muda Nugraha, Nasywa Fatihah Bintang