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All Journal Journal of Anesthesiology and Clinical Research Jurnal Pengabdian Masyarakat Bidang Sosial dan Humaniora
Beny Firmansyah
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Social Sciences

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Pharmacodynamic Mismatch in Adductor Canal Blockade: Dexamethasone Phosphate (Rapid-Salt) Outperforms Methylprednisolone Acetate (Depot-Suspension) for Early Mobilization Beny Firmansyah; Taufiq Agus Siswagama; Buyung Hartiyo Laksono
Journal of Anesthesiology and Clinical Research Vol. 6 No. 2 (2025): Journal of Anesthesiology and Clinical Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jacr.v6i2.820

Abstract

Introduction: The motor-sparing adductor canal block (ACB) is central to enhanced recovery after surgery (ERAS) protocols for knee surgery. Corticosteroid adjuvants are used to prolong analgesia, but a direct comparison of perineural Dexamethasone and Methylprednisolone is lacking. This study aimed to observe real-world associations between these adjuvants, postoperative pain, and functional recovery. Methods: This analytical, prospective, observational cohort study was conducted at a tertiary hospital from November 2024 to April 2025. Fifty-three patients undergoing knee surgery under subarachnoid anesthesia were enrolled. Following surgery, patients received an ultrasound-guided ACB with 20 mL of Ropivacaine 0.5% combined with either Dexamethasone 10 mg (n=24) or Methylprednisolone 60 mg (n=29), based on the attending anesthesiologist's preference. The primary functional outcome was time to mobilization. Secondary outcomes included Numerical Rating Scale (NRS) pain scores at 12, 24, and 48 hours. Results: A significant association was observed for the primary functional outcome: 87.5% of the Dexamethasone cohort mobilized within 24 hours, versus 62.1% of the Methylprednisolone cohort (p = 0.037). This functional advantage was congruent with a superior early analgesic profile; the Dexamethasone group reported significantly lower mean NRS scores at 12 hours (2.71 ± 0.81 vs. 3.86 ± 1.13; p < 0.001) and 24 hours (2.17 ± 0.56 vs. 3.24 ± 0.69; p < 0.001). A significant baseline difference in age distribution (p = 0.009) was identified as a key variable. Conclusion: This study provides the first clinical comparison of a rapid-acting salt (Dexamethasone Phosphate) versus a depot-suspension (Methylprednisolone Acetate) as perineural adjuvants in ACB. The observed superior functional and analgesic profile of Dexamethasone aligns with its pharmacokinetic properties, suggesting a pharmacodynamic mismatch between slow-release formulations and the pathophysiology of acute 24-hour postoperative pain.
Implementasi Ekonomi Hijau untuk Peningkatan Daya Saing dan Keberlanjutan: Pendampingan pada Pokmas Al-Fatihah Farm, Desa Jelbuk Khanifatul Khusna; Hari Sukarno; Salma Fauziyyah; Ro'isyatul Mu'amanah; Beny Firmansyah
ABDISOSHUM: Jurnal Pengabdian Masyarakat Bidang Sosial dan Humaniora Vol. 4 No. 4 (2025): Desember 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/abdisoshum.v4i4.6531

Abstract

This community service initiative was driven by the weak governance of micro-enterprises in rural areas, which hold significant economic potential but remain underutilized both managerially and ecologically. Pokmas Al-Fatihah Farm in Jelbuk Village, Jember Regency, serves as a case in point, focusing on the production of cassava-based plate chips. Despite the promising market opportunities, the group faced persistent challenges related to business management, pricing strategies, and production efficiency. By applying the Asset-Based Community Development (ABCD) approach, the program sought to embed green economy principles into the cooperative’s operations. The activities included training on simple financial record-keeping, the adoption of environmentally friendly appropriate technologies, and counseling on business efficiency and sustainability. The outcomes demonstrated a notable enhancement in members’ managerial capabilities, more efficient use of raw materials and energy, as well as the cultivation of ecological awareness in enterprise management. Ultimately, this program highlights a model of village-level economic empowerment that is both adaptive to environmental challenges and aligned with sustainable development goals.
Co-Authors Buyung Hartiyo Laksono Hari Sukarno Khanifatul Khusna Ro'isyatul Mu'amanah Salma Fauziyyah Taufiq Agus Siswagama