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All Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Eduvest - Journal of Universal Studies
Soesanto, Kiky Monica
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Aerospace Engineering Computer Science & IT Dentistry Health Professions Medicine & Pharmacology Neuroscience Social Sciences Veterinary

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Radiological Characteristics And Cognitive Disorders Of Dementia Patients At Prof. Dr. Hospital I.G.N.G Ngoerah Period September 2023 - September 2024 Rajagukguk, Fidelya Christy; Soesanto, Kiky Monica; Laksmidewi, Putri; Widyastuti , Ketut
Eduvest - Journal of Universal Studies Vol. 5 No. 11 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i11.52307

Abstract

Dementia is a progressive neurodegenerative disorder characterized by a decline in cognitive function. Identifying the relationship between radiological characteristics and the level of cognitive impairment can help early detection and intervention planning. This study aims to describe the radiological characteristics and level of cognitive impairment in dementia patients at Prof. Dr. I.G.N.G Ngoerah Hospital during the period September 2023-September 2024. The method used was a retrospective descriptive study of 31 patients who had been diagnosed with dementia at the Neurobehaviour polyclinic. The level of cognitive impairment was categorized into mild, moderate, and severe based on the MoCA-Ina score. Radiological characteristics were assessed through Global Cortical Atrophy (GCA), Medial Temporal Atrophy (MTA), Fazekas, and Koedam scores. Results showed that MTA scores tended to increase with the severity of cognitive impairment, with the severe dementia group having an MTA score of 4 at 100%. This finding indicates that a high MTA score is associated with a more severe decline in cognitive function. The implication of this study is the importance of brain radiology examination in predicting the progression of dementia, so that early interventions can be made to slow cognitive decline.
CEREBROSPINAL FLUID ANALYSIS IN TUBERCULOUS MENINGITIS: DIAGNOSTIC, PROGNOSTIC, AND MONITORING PERSPECTIVES Soesanto, Kiky Monica; Susilawathi, Ni Made; Sudewi, A.A. Raka
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 9 No 1 (2026): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Tuberculous meningitis (TBM) is the most severe form of extrapulmonary tuberculosis, associated with high morbidity and mortality. This review aims to evaluate the role of cerebrospinal fluid (CSF) analysis in the diagnosis and prognosis, particularly in relation to mortality, as well as in therapeutic monitoring of TBM. A narrative literature review was conducted using studies published between 2010 and 2025 on CSF parameters in TBM. Studies reporting associations between CSF biomarkers and clinical outcomes were included. Eighteen eligible studies were analyzed qualitatively. CSF analysis plays a critical role in classifying TBM as definite, probable, or possible according to the Lancet criteria. Elevated CSF protein (≥2 g/L) and reduced glucose (<2.2 mmol/L) levels are strongly associated with mortality, reflecting severe inflammation and blood-brain barrier dysfunction. Additional markers such as CSF lactate, inflammatory cytokines, and CRP further support prognostication. Serial measurements of CSF parameters aid in monitoring treatment response, especially in cases with atypical clinical progress. This review also highlights the diagnostic and monitoring roles of CSF parameters throughout the course of TBM. CSF biomarkers, especially protein and glucose levels, are key to assessing disease severity, predicting outcomes, and guiding treatment strategies in TBM. These findings support the integration of CSF analysis into routine clinical algorithms for managing this life-threatening condition. Keywords: cerebrospinal fluid, diagnosis, monitoring, prognosis, tuberculous meningitis DOI: 10.35990/mk.v9n1.p104-114
Co-Authors Laksmidewi, Putri Rajagukguk, Fidelya Christy Raka-Sudewi A. A. Susilawathi, Ni Made Widyastuti , Ketut