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All Journal Jurnal Kesehatan Indonesian Journal of Health Science
Kencana, Faradiyan
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Higher Risk of Preeclampsia Among Overweight and Obese Pregnant Women Compared to Normal BMI Women Kencana, Faradiyan; Prijanti, Ani Retno; Puwosunu, Yuditiya; Dinutanayo, Wimba Widagdo; Sari, Adinda Juwita
Jurnal Kesehatan Vol 16 No 3 (2025): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v16i3.4900

Abstract

Preeclampsia is a pregnancy complication characterized by hypertension and proteinuria, affecting 2–8% of pregnancies worldwide, with a prevalence of 24% in Indonesia. Its etiology remains unclear due to its complex, multifactorial nature, and several factors, such as age, obesity, pre-existing conditions, and multiple pregnancies, may influence its occurrence. This study aims to investigate the relationship between body mass index (BMI) and preeclampsia in pregnant women. An analytical observational study was conducted using purposive sampling, involving 18 participants in each group. Secondary data were obtained from medical records at Rumah Sakit Cipto Mangunkusumo, Rumah Sakit Budi Kemuliaan, and Puskesmas Senen. Statistical analysis was performed using the Chi-square test. Results show that 17 respondents (47.2%) with overweight or obesity had preeclampsia, whereas 8 respondents (22.2%) with normal BMI did not. The Chi-square test indicated a significant association between BMI and preeclampsia (p=0.007). Higher BMI is significantly associated with preeclampsia. Maintaining a healthy BMI during pregnancy may reduce the risk of this condition. 
Immunothrombosis as a bridge between innate immunity and hemostasis: A narrative review of emerging mechanisms Maulana, Anang Rizky; Nuriah, Cici; Kencana, Faradiyan
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1993

Abstract

Background: Immunothrombosis is an evolutionarily conserved host defense mechanism integrating innate immunity and hemostasis to limit pathogen dissemination through localized thrombus formation. While physiologically protective, dysregulated immunothrombosis contributes to thrombo-inflammatory diseases. Objective: This narrative review summarizes emerging cellular and molecular mechanisms linking innate immunity and coagulation, with emphasis on their pathological and therapeutic implications. Methods: A narrative literature review was conducted using Scopus-indexed journals retrieved from PubMed, Scopus, and ScienceDirect, prioritizing review articles and landmark original studies published between 2013 and 2025. Main Findings: Immunothrombosis is orchestrated by neutrophils, platelets, monocytes, endothelial cells, and complement systems through mechanisms including neutrophil extracellular trap (NET) formation, tissue factor expression, inflammasome activation, and immune–coagulation crosstalk. Conclusion: Immunothrombosis represents a fundamental biological bridge between innate immunity and hemostasis, offering novel therapeutic targets in thrombo-inflammatory disorders.
Co-Authors Ani Retno Prijanti Dinutanayo, Wimba Widagdo Maulana, Anang Rizky Nuriah, Cici Puwosunu, Yuditiya Sari, Adinda Juwita