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Alnawas, Zahraa Ali Nashoor
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Biochemical Profiles in Women with Parathyroid Carcinoma Under Chemotherapy Alnawas, Zahraa Ali Nashoor; Dikain, Kawther hussein
Academia Open Vol. 10 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.12989

Abstract

General Background: Parathyroid carcinoma is a rare endocrine malignancy characterized by excessive parathyroid hormone secretion and severe metabolic disruption. Specific Background: Although its biochemical profile is well documented, evidence describing how chemotherapy influences circulating calcium, phosphate, vitamin D metabolites, and trace elements—particularly among older women—remains limited. Knowledge Gap: Few studies systematically compare these biochemical alterations with healthy controls to determine the extent of treatment-associated metabolic derangement. Aims: This study evaluates and correlates key biochemical parameters in women with parathyroid carcinoma undergoing chemotherapy relative to age-matched healthy subjects. Results: Findings demonstrated significantly elevated serum calcium and parathyroid hormone, alongside reduced phosphate, 25(OH)D, 1,25(OH)₂D, zinc, and iron in the patient group, indicating marked disruptions across mineral metabolism, vitamin D dynamics, and trace element homeostasis. Novelty: The study provides one of the first integrated biochemical assessments focused exclusively on chemotreated female patients, revealing a broader metabolic signature than previously recognized. Implications: These results highlight the importance of comprehensive biochemical monitoring to improve diagnostic accuracy, evaluate treatment response, and anticipate complications, thereby supporting more precise management strategies for parathyroid carcinoma.Highlight : Elevated calcium and PTH are the key biochemical disturbances. Reduced phosphate and vitamin D indicate notable metabolic impairment. Trace element changes support the need for comprehensive biochemical evaluation. Keywords : Parathyroid Carcinoma, Hypercalcemia, Parathyroid Hormone (PTH), Vitamin D Deficiency, Hypophosphatemia
The Impact of Lactobacillus Infection During Pregnancy on Metabolic and Immune Parameters in Women 40 Days Post-Delivery: Dampak Infeksi Lactobacillus Selama Kehamilan terhadap Parameter Metabolik dan Imun pada Wanita 40 Hari Pasca Persalinan Alnawas, Zahraa Ali Nashoor; Dakhil, Kareema A.
Academia Open Vol. 10 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.13014

Abstract

Background: Lactobacillus normally plays a protective role in the maternal microbiome, yet under certain dysbiotic conditions it may be associated with metabolic and immunological disturbances during pregnancy. Specific Background: Evidence regarding postpartum health consequences of Lactobacillus infection remains limited, particularly its link to inflammatory and metabolic alterations. Gap: No studies have assessed metabolic and immune outcomes 40 days postpartum among women infected with Lactobacillus during pregnancy. Aim: This study examines postpartum metabolic profiles, inflammatory markers, and immune balance in women previously exposed to Lactobacillus infection. Methods: A cross-sectional comparison of 100 infected and 100 healthy women was conducted using clinical, biochemical, and immunological assessments. Results: Infected women exhibited higher fasting glucose, cholesterol, triglycerides, blood pressure, CRP, IL-6, IL-8, TNF-α, TPOAb, and TgAb, alongside lymphopenia and a Th1-dominant immune shift. Novelty: This study provides early evidence that Lactobacillus-associated dysbiosis in pregnancy may contribute to sustained metabolic and immune dysregulation beyond delivery. Implications: Findings highlight the importance of monitoring postpartum women with pregnancy-related dysbiosis and suggest a potential role of microbiome alteration in long-term maternal health. Highlights:• Distinct postpartum metabolic disturbances in infected women• Marked inflammatory activation associated with dysbiosis• Altered Th1/Th2 balance persisting after delivery Keywords: Lactobacillus Infection, Postpartum Metabolism, Immune Imbalance, Cytokines, Maternal Health
Transition Metal Complex of Oxadiazole as Dual Antidiabetic and Anti Hyperthyroid Agent Alnawas, Zahraa Ali Nashoor
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.305

Abstract

General background: 1,3,4-oxadiazole derivatives are well-established heterocycles with broad pharmacological potential, and metal coordination frequently enhances their therapeutic profiles. Specific background: Recent studies highlight the need for compounds capable of dual modulation of metabolic and endocrine disorders, particularly diabetes and hyperthyroidism, where single-target therapies often yield limited outcomes. Knowledge gap: Despite promising reports, few studies have integrated experimental pharmacology with quantum chemical modeling to explain how metal coordination influences biological potency. Aims: This research synthesized a new oxadiazole–indolinone ligand and its Co(II), Ni(II), Cr(III), and Fe(III) complexes and evaluated their antidiabetic and anti-hyperthyroid activities through in vivo assays supported by DFT calculations and molecular docking. Results: All complexes demonstrated dose-dependent activity, with Co(II) exhibiting the strongest glucose reduction (120 ± 7 mg/dL) and T₄ suppression (7.1 ± 0.4 µg/dL), consistent with superior docking affinities and favorable electronic descriptors. Novelty: This study correlates spectroscopic, computational, docking, and pharmacological findings in a unified structure–activity interpretation. Implications: The results indicate that metal coordination significantly boosts biological efficacy, positioning Co(II) complexes as strong candidates for future dual-action therapeutics in diabetes and hyperthyroidism.Highlight : Metal complexation improves biological effectiveness of the ligand. Co(II) complex shows the strongest dual activity based on results. Docking findings align with experimental data, supporting the SAR. Keywords : 1,3,4-Oxadiazole, Transition Metal Complexes, DFT, Molecular Docking, Antidiabetic and Anti-Hyperthyroid Activity
Co-Authors Dakhil, Kareema A. Dikain, Kawther hussein