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Alnawas, Zahraa Ali Nashoor
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Journal : Academia Open

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Biochemical Profiles in Women with Parathyroid Carcinoma Under Chemotherapy Alnawas, Zahraa Ali Nashoor; Dikain, Kawther hussein
Academia Open Vol. 10 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.12989

Abstract

General Background: Parathyroid carcinoma is a rare endocrine malignancy characterized by excessive parathyroid hormone secretion and severe metabolic disruption. Specific Background: Although its biochemical profile is well documented, evidence describing how chemotherapy influences circulating calcium, phosphate, vitamin D metabolites, and trace elements—particularly among older women—remains limited. Knowledge Gap: Few studies systematically compare these biochemical alterations with healthy controls to determine the extent of treatment-associated metabolic derangement. Aims: This study evaluates and correlates key biochemical parameters in women with parathyroid carcinoma undergoing chemotherapy relative to age-matched healthy subjects. Results: Findings demonstrated significantly elevated serum calcium and parathyroid hormone, alongside reduced phosphate, 25(OH)D, 1,25(OH)₂D, zinc, and iron in the patient group, indicating marked disruptions across mineral metabolism, vitamin D dynamics, and trace element homeostasis. Novelty: The study provides one of the first integrated biochemical assessments focused exclusively on chemotreated female patients, revealing a broader metabolic signature than previously recognized. Implications: These results highlight the importance of comprehensive biochemical monitoring to improve diagnostic accuracy, evaluate treatment response, and anticipate complications, thereby supporting more precise management strategies for parathyroid carcinoma.Highlight : Elevated calcium and PTH are the key biochemical disturbances. Reduced phosphate and vitamin D indicate notable metabolic impairment. Trace element changes support the need for comprehensive biochemical evaluation. Keywords : Parathyroid Carcinoma, Hypercalcemia, Parathyroid Hormone (PTH), Vitamin D Deficiency, Hypophosphatemia
The Impact of Lactobacillus Infection During Pregnancy on Metabolic and Immune Parameters in Women 40 Days Post-Delivery: Dampak Infeksi Lactobacillus Selama Kehamilan terhadap Parameter Metabolik dan Imun pada Wanita 40 Hari Pasca Persalinan Alnawas, Zahraa Ali Nashoor; Dakhil, Kareema A.
Academia Open Vol. 10 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.13014

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Background: Lactobacillus normally plays a protective role in the maternal microbiome, yet under certain dysbiotic conditions it may be associated with metabolic and immunological disturbances during pregnancy. Specific Background: Evidence regarding postpartum health consequences of Lactobacillus infection remains limited, particularly its link to inflammatory and metabolic alterations. Gap: No studies have assessed metabolic and immune outcomes 40 days postpartum among women infected with Lactobacillus during pregnancy. Aim: This study examines postpartum metabolic profiles, inflammatory markers, and immune balance in women previously exposed to Lactobacillus infection. Methods: A cross-sectional comparison of 100 infected and 100 healthy women was conducted using clinical, biochemical, and immunological assessments. Results: Infected women exhibited higher fasting glucose, cholesterol, triglycerides, blood pressure, CRP, IL-6, IL-8, TNF-α, TPOAb, and TgAb, alongside lymphopenia and a Th1-dominant immune shift. Novelty: This study provides early evidence that Lactobacillus-associated dysbiosis in pregnancy may contribute to sustained metabolic and immune dysregulation beyond delivery. Implications: Findings highlight the importance of monitoring postpartum women with pregnancy-related dysbiosis and suggest a potential role of microbiome alteration in long-term maternal health. Highlights:• Distinct postpartum metabolic disturbances in infected women• Marked inflammatory activation associated with dysbiosis• Altered Th1/Th2 balance persisting after delivery Keywords: Lactobacillus Infection, Postpartum Metabolism, Immune Imbalance, Cytokines, Maternal Health
Co-Authors Dakhil, Kareema A. Dikain, Kawther hussein