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All Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health
Mustaqim, R. Fuad
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
Health Professions Public Health

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Partial Hydatidiform Mole with Subclinical Hyperthyroidism - A Case Report Mustaqim, R. Fuad; Aditiyono, Aditiyono; Winarno, Gatot N.A.; Suhartomo, Dalri Muhammad
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 2 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i2.24775

Abstract

Partial hydatidiform mole is a rare gestational trophoblastic disease marked by triploid karyotype, fetal abnormalities, and growth disorders, sometimes accompanied by subclinical hyperthyroidism. Diagnosis relies on β-hCG testing, ultrasound, and immunohistochemistry. Management, especially regarding chemotherapy, remains debated due to fertility concerns. This case report presents a rare instance of partial hydatidiform mole with subclinical hyperthyroidism, emphasizing key diagnostic and therapeutic considerations. A case report 22-year-old primigravida at 16 weeks presented with abortion imminens, placentomegaly, anemia, and massive bleeding. Evaluation confirmed a partial mole with subclinical hyperthyroidism. She was stabilized for hemorrhagic shock and IUFD, then underwent molar evacuation and caesarean hysterectomy. Although chemotherapy was initially planned, β-hCG levels normalized within 4 months without it, and follow-up showed no malignant transformation or recurrence. Low-risk partial hydatidiform mole can regress without chemotherapy, but comorbidities like subclinical hyperthyroidism require attention. At least 6 months of β-hCG monitoring is essential to confirm resolution and detect complications. Keyword: Chemotherapy, Hyperthyroid Subclinical, Partial Hydatidiform Mole.
Co-Authors Aditiyono, Aditiyono Suhartomo, Dalri Muhammad Winarno, Gatot N.A.