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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ
Sumantri Abdullah, Surya
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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Physicochemical Profile of Red Ginger (Zingiber officinale) SNEDDS as Potential Antidiabetic Sumantri Abdullah, Surya; Sudewi, Sri; Antasionasti, Irma; Rezky Putri Indarwati Abdullah
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64731

Abstract

This study developed a Self-Nanoemulsifying Drug Delivery System (SNEDDS) of red ginger (Zingiber officinale var. rubrum) to enhance its stability and bioavailability. 8 formulations (F1–F8) were tested with varying Tween 80 : PEG 400 ratios (Smix 4.5 mL). Formula F7 (2.8 : 1.8 mL) produced a water-clear emulsion with pH 5.20 ± 0.02 and excellent stability for 28 days. PSA results showed droplet size 20.33 ± 0.57 nm, PDI 0.430 ± 0.053, and zeta potential −19.58 ± 1.50 mV. These findings indicated that F7 is the optimum, physicochemically stable SNEDDS formulation, potentially improving solubility and oral bioavailability of red ginger’s active compounds as a phytopharmaceutical antidiabetic candidate Keywords: red ginger, SNEDDS, nanoemulsion, physicochemical stability
Co-Authors Abdullah, Rezky Putri Indarwati Antasionasti, Irma Sri Sudewi, Sri