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Fadhilah, Nadiah Farah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology

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POTENTIAL OF SACHA INCHI (Plukenetia volubilis L.) AS AN ANTICANCER : A SYSTEMATIC REVIEW Fadhilah, Nadiah Farah; Nastiti, Chyntia Tresna; Zuhri, Fuad Minan
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.105-118

Abstract

Cancer is the leading cause of death worldwide. WHO estimated 20 million new cancer cases and 9.7 million deaths in 2022. The increasing incidence of cancer encourages development of new therapeutic agents for higher patient survival rate. Plant products are widely studied, one of which is Sacha Inchi (Plukenetia volubilis L.) extract. Sacha Inchi is known to have contents with anticancer potential, but information regarding its effectiveness is still limited. This systematic review aims to provide in-depth review on studies focus on anticancer potential of Sacha Inchi. The searching process was conducted in 4 databases such as National Library of Medicine (MEDLINE-PubMed), Scopus, Springerlink, and Sciencedirect. Keywords used were combination of "sacha inchi”, "plukenetia volubilis”, "anticancer”, "antineoplastic”, "antiproliferative”. Studies selection and data extraction obtained 17 studies provided information on extracts of Sacha Inchi plants and their anticancer-potential contents, both in vitro and in vivo. Polyunsaturated fatty acids and phenolic compounds were the most identified compounds. Other identified substances were tocopherols, peroxides, amino acids, steroids, terpenoids, flavonoids, proteins. Included studies showed antioxidant and anticancer potential of Sacha inchi.
Co-Authors Nastiti, Chyntia Tresna Zuhri, Fuad Minan