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All Journal Journal of Science and Technology Research for Pharmacy
Mohammad Alauhdin
Universitas Negeri Semarang
Medicine & Pharmacology

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Comparison of Eco - Scale Between UV - Vis Spectrophotometry and Thin Layer Chromatography - Densitometry Methods on The Determinination of Retinoic Acid in Facial Cream Preparations Zaneta Nur Faida; Mohammad Alauhdin
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 1 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i1.5415

Abstract

Retinoic acid, a compound derived from vitamin A and its active metabolites, is often found in cream preparations and can be used without a doctor's prescription. This research aims to analyze the retinoic acid content in facial cream preparations and determine the environmental friendliness of the analytical method used. The materials used in this research were PBFI retinoic acid, methanol, TLC plates, n-hexane, acetone, and three facial cream samples. UV - Vis Spectrophotometry and Thin Layer Chromatography - Densitometry are methods used for assay analysis and Eco - Scale is a method for determining greenness. The research found that three cream samples tested positive for retinoic acid, which has been banned by BPOM since 1999. The UV-Vis Spectrophotometry method measured retinoic acid content of 0.103%, 0.266% and 0.256%, with a total score of 24 points. The Thin Layer Chromatography - Densitometry method measured retinoic acid content of 0.0213%, 0.0314%, and 0.027%, with a score of 50 points. It can be concluded that the UV - Vis Spectrophotometry method is more environmentally friendly compared to the Thin Layer Chromatography - Densitometry method based on Eco - Scale analysis.
Detection and Determination of Captopril Using Silver Nanoparticles Based Colorimetric Method Anida Hasna Rahmatika; Mohammad Alauhdin
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 1 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i1.8593

Abstract

Basic Health Research (Riskesdas) in 2018 showed an increase in the prevalence of hypertension in Indonesia. Captopril is one of the antihypertensive drugs that is often prescribed because it is affordable and effective in lowering blood pressure, but captopril also has several side effects. Therefore, the development of sensitive, simple, rapid and cost-effective analytical techniques for the determination of captopril is urgently needed. This research aims to develop a colorimetric detection of captopril using silver nanoparticles and analyze its performance in measuring the captopril in tablet samples. The parameters studied include linearity, sensitivity, accuracy and precision. The results of the research show that silver nanoparticles can be used for qualitative detection of captopril which is characterized by a color change and absorbance decrease of the sample solution. The results of the performance test of the developed method showed good results. The linearity test showed a correlation coefficient (r) of 0.9915 with the regression equation obtained was y = 0.263x + 129.26. The limit of detection (LOD) value is 0.0206 ppm and the limit of quantitation (LOQ) is 0.0687 ppm. In the accuracy test results, the recovery percentage (%recovery) was 95.3% and the precision test with the relative standard deviation (%RSD) obtained was 0.85%. The captopril content obtained in the 50 mg captopril tablet sample preparation was 98.0%.
Optimization of The Concentration of Precipitation Reagent in Cyclamate Analysis and Determination of Cyclamate Contents in Jamu Sistia Asfa Fiqrotinnisa; Mohammad Alauhdin
Journal of Science and Technology Research for Pharmacy Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v3i2.9329

Abstract

: Sodium cyclamate is one of the food additives sweeteners that are often added to food products including jamu. It has a low price and a taste 30 - 50 times sweeter than natural sugar. It is known that excessive & longterm use of sodium cyclamate can cause adverse health effects. Currently, the standard method used to detect the presence of cyclamate refers to the precipitation method of SNI 01-2893. However, the level of sensitivity of the method is unknown. This study aims to determine the sensitivity of the precipitation method of SNI 01-2893, as well as to optimize reagents that have better sensitivity to be used as a reference for cyclamate precipitation reagents and applied to measure cyclamate in jamu. The determination the method’s sensitivity is based on the smallest concentration of cyclamate standard that can be detected by the method. Optimization of the precipitation reagent was carried out on 6 variations of precipitation reagent concentration to obtain a new formula that has a better sensitivity than the SNI 01-2893 method. Jamu samples were tested using the new optimized reagent formula. The result showed the detection limit of the of SNI 01-2893 method is 5 ppm. Optimization of the precipitation reagent formula with the composition of HCl 10%, BaCl2 10%, and NaNO2 20% showed as the highest sensitivity. It was marked by an increase in the amount of precipitate formed and had a detection limit of up to 0.9 ppm. Based on testing using the new reagent, 9 out of 10 jamu samples were positive for cyclamate. The cyclamate levels of the 9 jamu samples were measured using the spectrophotometric method, the results showed cyclamate levels are in the range of 4.3 - 6.32 mg/kg sample and meeting BPOM requirements.
Co-Authors Anida Hasna Rahmatika Sistia Asfa Fiqrotinnisa Zaneta Nur Faida