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All Journal Jurnal Kartika Kimia Jurnal Pengabdian Kesehatan Journal of Science and Technology Research for Pharmacy
Tri Minarsih
Universitas Negeri Semarang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Effect of Nanotechnology in the Formulation of Butterfly Pea Flower (Clitoria Ternatea) Extract Cream on the Antibacterial Activity of Acne-Causing Propionibacterium acnes Chrisabela Bia; Tri Minarsih
Journal of Science and Technology Research for Pharmacy Vol. 5 No. 1 (2025): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v5i1.27310

Abstract

Acne is a chronic inflammatory skin disease caused by the bacteria Propionibacterium acnes. Common therapy using topical antibiotics can cause resistance if used long term. It is necessary to develop therapy using natural ingredients of butterfly pea flower (Clitoria ternatea) which has the potential for antibacterial activity and is made into a cream formulation with nanoparticle technology that can increase drug bioavailability. This study used an experimental method with the stages of maceration extraction of butterfly pea flowers using 96% ethanol, making nanoparticle extracts using the ionic gelation method (sodium alginate and CaCl₂), and making nanocreams using the high-energy emulsification method. The formulation formulations consisted of formula 1 extract cream, formula 2 extract nanoparticle cream, and formula 3 butterfly pea flower extract nanocream with a concentration of 5%. Particle size characterization was carried out using the Particle Size Analyzer (PSA), while the antibacterial activity test was carried out using the well diffusion method against Propionibacterium acnes bacteria. The characterization results showed that the size of the extract nanoparticles was 378 nm, the extract nanoparticle cream was 4402 nm, and the nanocream was 465 nm. Physical evaluation showed that all three formulas met good standards and were classified as O/A type creams. The nanocream formulation had the highest antibacterial activity with an average inhibition zone of 6.3 mm (moderate category), while the extract cream and extract nanoparticle cream showed lower inhibition, 4.2 mm and 1 mm respectively (weak category), so that the telang flower extract nanocream formulation was the most effective in inhibiting the growth of Propionibacterium acnes.
Optimisation of SSG (Sodium Starch Glycolate) and Avicel PH 102 in the Formula of Orally Disintegrating Acetaminophen Tablets by Simplex Lattice Design Method Oktaviani Himmayatin Nisaa; Tri Minarsih
Journal of Science and Technology Research for Pharmacy Vol. 5 No. 2 (2025): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v5i2.27572

Abstract

Background: ODT acetaminophen tablets are an alternative drug therapy for patients who have difficulty in swallowing tablets or capsules. Additional ingredients that play an important role in the ODT tablet formula are disintegrants. The disintegrants used in this study were avicel ph 102 and SSG. The use of disintegrants can help increase the dissolution rate and accelerate the destruction time. Aim: The purpose of this study was to determine the optimum formula of ODT acetaminophen tablets and analyse the effect of SSG and avicel ph 102 on dissolution and disintegration time. Material and Methods: Determination of acetaminophen ODT tablet formula was carried out running in design expert software with the simplex latice design method. Preparation of ODT acetaminophen tablets was carried out by direct felting. The evaluation of ODT acetaminophen tablets was IPC physical evaluation, determination of content, and dissolution. Determination of the optimum formula was done by simplex latice design method. Results: The results showed that all ODT acetaminophen tablet formulas fulfilled all the requirements of the IPC test, physical evaluation, dissolution, and determination of levels according to the Pharmacopoeia VI edition standards. Formula 3 produced the fastest disintegration time of 3 minutes, but the dissolution rate of 100% was reached in the 15th minute. It is suspected that gel formation in the SSG swelling mechanism slowed down the dissolution rate. While formulas 1, 2, and 4 which have a longer disintegration time reached >80% dissolution in the 10th minute. Conclusion: The optimum formula results with the simplex latice design method were SSG 8% and avicel ph 102 7%.  Avicel ph 102 and SSG had the effect of accelerating the destruction time and slowing down the dissolution rate.
Antioxidant Activity of Porang (Amorphophallus muelleri) Leaves Ethanol Extract and Its Application as Cream Preparation Willy Tirza Eden; Erlina Sari; Endah Widhihastuti; Tri Minarsih; Senda Kartika Rakainsa
Jurnal Kartika Kimia Vol 9 No 1 (2026): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v9i1.915

Abstract

Antioxidants are compounds that can overcome the effects of free radicals. One of the plants that has antioxidant activity is the Porang plant (Amorphophallus muelleri). This study aims to determine the antioxidant activity of the Porang leaves’ ethanol extract and fraction using the DPPH method. Porang leaves were extracted using maceration with 96% ethanol and separated by fractionation using n-hexane and ethyl acetate. The ethanol extract and the three fractions were tested for their activity as antioxidants using the DPPH method with ascorbic acid as positive control. Phytochemical screening and Total Flavonoid Content (TFC) assay were also conducted. Phytochemical screening showed the presence of flavonoids, tannins/polyphenols, and terpenoids. Quantitative test for Total Flavonoid Content (TFC) showed that the greatest flavonoid content was found in the ethyl acetate fraction, which was 101.93 ± 2.75 mgQE/g. The results showed that the strongest antioxidant activity was possessed by ethanol extract (IC50 66.39 ± 0.44 µg/mL), followed by the ethyl acetate fraction (IC50 72.19 ± 4.37 µg/mL), ethyl acetate insoluble fraction (IC50 135.48 ± 2.54 µg/mL), and the weakest was n-hexane fraction (IC50 198.31 ± 16.75 µg/mL). Hence, cream was prepared using ethanol extract which possesses the strongest antioxidant activity. Formula 4 (7.5% extract) showed the strongest antioxidant activity (IC50 1,637.12 µg/mL), followed by formula 3 (5% extract) with IC50 of 2590.377 µg/mL, formula 2 (2.5% extract) with IC50 of 3,898.694 µg/mL, and formula 1 (cream base) with IC50 of 110,727.4 µg/mL. All cream formulations which contained porang leaves extract (F2 – F4) had higher antioxidant activity than formula 1 (base), although their antioxidant activity was classified as very weak.
Peningkatan Pengetahuan dan Keterampilan Pemilihan Kosmetik yang Legal dan Aman Pada Masyarakat Kelurahan Kandri Tri Minarsih; Lindra Anggorowati; Arroyani Asa Dilaga; Faradila Elsa Anggraeni; Weka Nabil Ubhayahita; Rifqi Muhammad Hajid
Jurnal Pengabdian Kesehatan Vol 8, No 3 (2025): Jurnal Pengabdian Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jpk.v8i3.483

Abstract

Kosmetik merupakan salah satu kebutuhan pokok, khususnya  bagi kaum perempuan, agar dapat berpenampilan cantik dan menarik. Banyak penelitian yang menyebutkan adanya kandungan bahan-bahan berbahaya yang ditambahkan kedalam kosmetik, sehingga pemilihan kosmetik harus diperhatikan, agar kosmetik yang digunakan aman dan tidak membahayakan kesehatan. Kelurahan Kandri merupakan Kelurahan Wisata di Gunungpati, sehingga masyarakatnya, khususnya kaum perempuan, dituntut untuk betpenampilan menarik.  Pengabdian masyarakat ini bertujuan untuk melakukan edukasi tentang cara memilih kosmetik yang legal dan  aman dengan mengakses Cek BPOM serta  berbagai macam bahan berbahaya yang terdapat didalam kosmetik, serta efeknya terhadap kesehatan pada masyarakat Kelurahan Kandri. Kegiatan pengabdian ini dilakukan dengan melakukan penyuluhan tentang kosmetik, bahan berbahaya yang terdapat di dalam kosmetik serta bahayanya terhadap kesehatan. Selain itu dilakukan kegiatan pelatihan cara melakukan pengecekan nomer registrasi kosmetik pada Cek BPOM.Pengabdian masyarakat ini merupakan menggunakan metode crosssectional. Instrumen yang digunakan berupa kuesioner dengan metode pretest dan post test dengan membandingkan pengetahuan yang dimiliki masyarakat, sebelum dan sesudah diberikan edukasi.  Responden dalam kegiatan ini adalah penduduk di Kelurahan Kandri. Rata- rata nilai pretest sebelum diberikan edukasi sebesar 76,54 sedangkan setelah diberikan edukasi sebesar 87,31. Hasil uji statistic menggunakan uji t test berpasangan dengan nilai p 0,05 menunjukkan terdapat perbedaan pemahaman pengetahuan yang signifikan. Sehingga kegiatan Pengabdian Masyarakat ini mampu menambah wawasan dan meningkatkan pemahaman peserta tentang kosmetik yang aman.
Co-Authors Arroyani Asa Dilaga Chrisabela Bia Erlina Sari Faradila Elsa Anggraeni Lindra Anggorowati Oktaviani Himmayatin Nisaa Rifqi Muhammad Hajid Senda Kartika Rakainsa Weka Nabil Ubhayahita Widhihastuti, Endah Willy Tirza Eden, Willy Tirza