Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health
Amina Diarsy
Magister of Midwifery, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
Health Professions Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Reduction of VEGF Levels by Phaleria macrocarpa Flavonoids in an Endometriosis Mouse (Mus musculus) Model Amina Diarsy; Fany Hardiati Amalia; Sutrisno Sutrisno; Tatit Nurseta; Safrina Dewi Ratnaningrum
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25355

Abstract

Endometriosis occurs when endometrial-like cells proliferate at ectopic sites outside the uterus. The advancement of endometriotic lesions is strongly influenced by VEGF, as it stimulates the formation of new blood vessels. In contrast, flavonoids derived from Phaleria macrocarpa extract possess inhibitory effects on both pro-inflammatory signaling molecules and pro-angiogenic pathways. This study investigated the effects of flavonoids from Phaleria macrocarpa extract on VEGF levels in the peritoneal fluid of endometriosis mouse models. This research employed a post-test-only control group experimental design. A total of thirty mice (Mus musculus) were assigned to six groups: a healthy control group, an untreated endometriosis group, and four endometriosis groups receiving isolated flavonoids from Phaleria macrocarpa extract at doses of 3.75, 7.5, 15, and 30 mg/mouse/day (n=5). Peritoneal fluid samples were collected from all groups to examine VEGF levels using ELISA. The results were expressed as mean ± SD and subsequently evaluated using a one-way ANOVA with LSD post-hoc test at a significance level of p-value < 0.05. Flavonoids at the dose of 30 mg/day significantly decreased the VEGF levels compared to the group of endometriosis mouse models (p-value=0.001). Flavonoids decreased VEGF levels as an angiogenic factor in peritoneal fluid, which may play a role in the proliferation of endometriosis tissue. Keywords: Flavonoid, Phaleria macrocarpa, VEGF, Endometriosis
Co-Authors Fany Hardiati Amalia Safrina Dewi Ratnaningrum Sutrisno Sutrisno Tatit Nurseta