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All Journal Acta Pharmaceutica Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian
Putri, Mulan Gevika Amara
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Health Professions Medicine & Pharmacology

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ANALISIS BIBLIOMETRIK TREN DAN KEBAHARUAN STUDI PERMEABILITAS DENGAN CHEMINFORMATICS BERBASIS DATAWARRIOR Matthew Valentino, Tambunan; Putri, Mulan Gevika Amara; Damayanti, Ni Ketut Anggun; Sianturi, Tiarma Kristiana
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25181

Abstract

Cheminformatics is a discipline that employs computational methods on chemical data and has emerged as a cutting-edge approach in pharmaceutical sciences. DataWarrior, an open-source software that integrates big data, offers a variety of features to support cheminformatics studies. This study aims to examine permeability research using DataWarrior-based cheminformatics and evaluate the potential for research innovation, particularly within the field of pharmacy. A bibliometric analysis using the Dimensions, Biblioshiny, and ResearchRabbit databases reveals that publications on permeability studies employing DataWarrior have increased, although the number of citations has declined due to a lack of novelty in the topics. Moreover, the limited use of the keyword "cheminformatics" in permeability studies indicates that the connection between these two fields needs to be strengthened. The integration of pharmacokinetic and physicochemical data via DataWarrior enables the development of more reliable methods by enhancing the prediction of compound similarity through its built-in descriptors, thereby supporting the practicality of molecular permeability and pharmacokinetic studies for new compounds. On the other hand, this research potential for Indonesia to increase its contributions to publications and citations in this field.
Perbandingan Kadar Tablet Parasetamol-Kafein Dengan Metode SSE dan Zero Crossing Dalam Pelarut NaOH dan Akuades Damayanti, Ni Ketut Anggun; Putri, Mulan Gevika Amara; Dewi, Ni Komang Tria Pradnyani; Yoga, Ida Bagus Ketut Widnyana; Valentino, Tambunan, Matthew
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.36075

Abstract

Metode Simple Simultaneous Equation (SSE) dan Zero Crossing (ZC) pada spektrofotometri UV-Vis digunakan untuk menentukan kadar parasetamol dan kafein dalam tablet kombinasi dengan pelarut NaOH 0,1 N dan akuades. Penelitian ini bertujuan membandingkan kedua metode serta pengaruh pelarut terhadap hasil kadar. Penentuan panjang gelombang maksimum (λmaks) dilakukan pada 243 nm dan 273 nm untuk akuades, serta 257 nm dan 272 nm untuk NaOH 0,1 N. Hasil menunjukkan pelarut NaOH 0,1 N menghasilkan kadar parasetamol sebesar 100,9% dan kafein 99,7% pada metode SSE, sedangkan pada metode ZC kadar parasetamol 103,5% dan kafein 102,6%. Pada pelarut akuades, kadar parasetamol dan kafein berturut-turut sebesar 94,8% dan 97,0% dengan SSE serta 95,6% dan 97,4% dengan ZC. Metode ZC menghasilkan kadar lebih tinggi dibandingkan SSE, dan pelarut NaOH 0,1 N memberikan hasil kadar lebih besar dibandingkan akuades. Kedua metode menunjukkan linearitas tinggi (R² > 0,995) dan presisi baik (RSD < 2%), sehingga dapat digunakan untuk analisis simultan parasetamol dan kafein secara cepat dan ekonomis.
Co-Authors Damayanti, Ni Ketut Anggun Dewi, Ni Komang Tria Pradnyani Matthew Valentino, Tambunan Sianturi, Tiarma Kristiana Valentino, Tambunan, Matthew Yoga, Ida Bagus Ketut Widnyana