Abstract: Entering young adulthood involves significant role transitions and increasing responsibilities that require effective psychological adaptation. For individuals raised in single-parent families, limited parental support and the absence of one parental figure may pose additional challenges to psychological well-being. Therefore, this study aims to examine the role of self-compassion in promoting psychological well-being among young adults from single-parent families. This study employed a quantitative approach using a cross-sectional design, with data collected through self-report questionnaires and analyzed using simple linear regression. A total of 130 young adults from single-parent families participated in the study through purposive sampling. The findings reveal that self-compassion significantly contributes to psychological well-being (p < 0.05), with a coefficient of determination (R²) of 0.481, indicating that self-compassion accounts for 48.1% of the variance in psychological well-being. Both self-compassion and psychological well-being were found to be at moderate levels among participants. These results suggest that fostering self-compassion may serve as an effective internal resource to support psychological well-being in young adults facing family-related adversities. The originality of this study lies in its focus on young adults raised by a single parent due to parental loss, highlighting self-compassion as a key protective factor within this specific population and contributing empirical evidence to the growing literature on positive psychological resources in vulnerable family contexts.