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Yudianto Budi Saroyo
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Triple-Threat Pregnancy: Navigating PPCM, Preeclampsia, and Thalassemia Major – A Holistic Reproductive Risk Assessment Post-Cesarean Delivery Arya Ady Nugroho; Yudianto Budi Saroyo; Dwiana Ocviyanti
MEDICINUS Vol. 39 No. 1 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/qdxs3625

Abstract

Background: Pregnancies complicated by multiple severe maternal conditions such as peripartum cardiomyopathy (PPCM), preeclampsia, and β-thalassemia major, pose significant risks to both mother and fetus. This case explores the challenges of managing a high-risk pregnancy, involving these conditions and highlights the importance of a multidisciplinary approach in high-risk pregnancy management.Case presentation: A 33-year-old pregnant woman with β-thalassemia major presented at 32+4 weeks of gestation with acute dyspnea, severe preeclampsia, and signs of PPCM. She was carrying dichorionic diamniotic twins and required emergency cesarean section after stabilization. Echocardiography revealed severe left ventricular systolic dysfunction with an ejection fraction of 35%. The patient underwent immediate postoperative management and received a trans-cesarean intrauterine device (IUD) insertion for long-term contraception. Both neonates were admitted to the neonatal intensive care unit (NICU) for prematurity care.Conclusion: This case underscores the critical need for a holistic, multidisciplinary approach in managing complex highrisk pregnancies, focusing on immediate maternal stabilization, neonatal care, and long-term reproductive planning.
Preeclampsia in the Modern Era: New Insights from Global Research and Implications for Practice in Indonesia Arya Ady Nugroho; Yudianto Budi Saroyo; Allan Taufiq Rivai
MEDICINUS Vol. 39 No. 2: MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/v8ne8639

Abstract

Preeclampsia (PE) remains a leading cause of maternal and neonatal morbidity and mortality worldwide, affecting 2–15% of pregnancies. This review synthesizes recent advancements in the understanding of PE pathophysiology, includingplacental dysfunction, endothelial impairment, and novel biomarkers such as angiogenic factors. Drawing on global studies published up to 2025, we explore predictive models for early detection before 11 weeks of gestation, innovativemanagement strategies including aspirin prophylaxis, and disparities in maternal and neonatal outcomes. In Indonesia, where PE contributes to 26–30% of maternal deaths, we highlight local epidemiology, risk factors such as anemia and obesity, and tailored interventions to improve screening and care in resource-limited settings. By emphasizing evidencebasedpractices, this article underscores the need for integrated approaches to reduce the burden of PE and provides actionable insights for clinicians in both global and Indonesian contexts.
Co-Authors Allan Taufiq Rivai Arya Ady Nugroho Dwiana Ocviyanti