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Worocahyo, Avis Meyvika
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Education Medicine & Pharmacology Neuroscience Public Health

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Hubungan Hipertensi dengan Penyakit Jantung Koroner (PJK): Tinjauan Pustaka Worocahyo, Avis Meyvika; Kurniati, Intanri; Damayanti, Putri; Susianti, Susianti
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1694

Abstract

Coronary Artery Disease (CAD) is still one of the leading causes of mortality worldwide, including in Indonesia with a steadily rising prevalence. Hypertension is recognized as a major risk factor, as it accelerates atherosclerosis, induces endothelial dysfunction, and promotes cardiac structural changes that ultimately lead to coronary artery narrowing. This study employed a literature review approach by analyzing scientific articles discussing the association between hypertension and CAD in Indonesia. The findings show a significant relationship between hypertension and CAD, with p-values < 0.05 across multiple studies, and hypertensive individuals found to be more than twice as likely to develop CAD compared to normotensive individuals. Pathophysiologically, chronic hypertension contributes to hemodynamic disturbances, cardiac remodeling, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system (RAAS), thereby accelerating atherosclerosis and triggering myocardial infarction. These results highlight the importance of early detection and effective management of hypertension as essential strategies for preventing cardiovascular complications.
Co-Authors Damayanti, Putri Intanri Kurniati Susianti, Susianti