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All Journal Jurnal Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Inovatif Jurnal Pengabdian Masyarakat Inovatif
Nanda Asyura Rizkyani
Pharmacy Study Program, Faculty Of Mathematics And Science, Universitas Pakuan, Bogor
Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Medicine & Pharmacology Social Sciences Other

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Immunostimulant Effects of Bitter Leaves (Gymnanthemum amygdalinum (Del.) Sch.Bip.ex Walp.) Leaf Extract Setiani, Lusi Agus; Wiendarlina, Ike Yulia; Rizkyani, Nanda Asyura; Fazri, Syifa Ainun
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

In Indonesia, the widespread impact of COVID-19 has led to an increased interest in exploring natural immunostimulants as complementary therapies. One promising candidate is Gymnanthemum amygdalinum, commonly known as bitter leaf. Bitter leaf is a medicinal plant that can be used as an immunostimulant because it contains flavonoid compounds. This study aims to investigate the immunostimulatory effects of Bitter leaf extract obtained using the MAE method, particularly in enhancing immune function and the effective dosage in rats. The ethanolic extract of bitter leaf was made using the microwave-assisted extraction (MAE) method, which can potentially extract high levels of flavonoid compounds compared to other extraction methods in vivo. There were as many as 25 rats, which were divided into five treatment groups: the negative control was treated with CMC Na 0,5% (w/v); the positive control was treated with 4,5 mg/200 g body weight (BW) of Echinacea purpurea. The treatment groups from Dose 1; Dose 2; and Dose 3 were treated with an ethanol extract of bitter leaf at 14 mg/200 g BW, 28 mg/200 g BW, and 56 mg/200 g BW. Immunostimulant effect testing was carried out using the carbon clearance method, and the number of leukocytes was counted. In carbon clearance testing, each group was given a carbon solution intravenously; blood was taken at 5, 10, and 15 minutes via the tail vein, and its absorbance was measured using UV-Vis 675 nm. The count of leukocytes was observed using the chamber of a hemocytometer through a microscope. The research results showed that administration of doses I, II, and III provided an immunostimulant effect. Based on the results, the ethanolic extract from a bitter leaf from Dose III (56 mg/200 g BW) provided a stronger immunostimulant effect in rats based on the phagocytosis index parameters of (9.005) and the number of leukocytes of (8,370/µL).
Community Engagement Through Health Education on Tuberculosis (TB) During World Pharmacist Day 2025 Nanda Asyura Rizkyani; Nhestricia, Nhadira; Setiani, Lusi Agus; Gunawan, Wawan; Yenni, Tengku
Jurnal Pengabdian Masyarakat Inovatif Vol. 3 No. 2 (2025): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v3i2.207

Abstract

Tuberculosis (TB) remains a major public health challenge in Indonesia. Pharmacists play a crucial role in strengthening community awareness, promoting early detection, and supporting treatment adherence. Community education activities are essential to empower the public with accurate knowledge and preventive practices. To describe the implementation and outcomes of TB health education conducted as part of the World Pharmacist Day (WPD) 2025 celebration in Bogor City and to evaluate its contribution to improving community awareness regarding TB. A community engagement activity was conducted on 25 September 2025 at Taman Heulang, Bogor. The program included health promotion through group exercise, pharmacist-led TB education, distribution of educational media, and direct one-on-one counseling. Preparatory activities, collaboration with stakeholders, and dissemination of 700 educational materials were documented. The activity involved 268 participants from IAI Kota Bogor and more than 300 community members attending the routine exercise program. TB education delivered by the Kopi TB team improved participants’ understanding of TB symptoms, transmission, prevention, and treatment adherence. Educational flyers and stickers served as effective reinforcement tools, expanding information reach within the community. The collaborative approach between pharmacists, local health authorities, and community groups facilitated high engagement and smooth execution of the program. The WPD 2025 community engagement activity successfully enhanced public awareness of TB and demonstrated the vital role of pharmacists in health promotion. Continued multidisciplinary collaboration is recommended to strengthen community-based TB control efforts.
Community Engagement Through Health Education on Tuberculosis (TB) During World Pharmacist Day 2025 Nanda Asyura Rizkyani; Nhestricia, Nhadira; Setiani, Lusi Agus; Gunawan, Wawan; Yenni, Tengku
Jurnal Pengabdian Masyarakat Inovatif Vol. 3 No. 2 (2025): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v3i2.207

Abstract

Tuberculosis (TB) remains a major public health challenge in Indonesia. Pharmacists play a crucial role in strengthening community awareness, promoting early detection, and supporting treatment adherence. Community education activities are essential to empower the public with accurate knowledge and preventive practices. To describe the implementation and outcomes of TB health education conducted as part of the World Pharmacist Day (WPD) 2025 celebration in Bogor City and to evaluate its contribution to improving community awareness regarding TB. A community engagement activity was conducted on 25 September 2025 at Taman Heulang, Bogor. The program included health promotion through group exercise, pharmacist-led TB education, distribution of educational media, and direct one-on-one counseling. Preparatory activities, collaboration with stakeholders, and dissemination of 700 educational materials were documented. The activity involved 268 participants from IAI Kota Bogor and more than 300 community members attending the routine exercise program. TB education delivered by the Kopi TB team improved participants’ understanding of TB symptoms, transmission, prevention, and treatment adherence. Educational flyers and stickers served as effective reinforcement tools, expanding information reach within the community. The collaborative approach between pharmacists, local health authorities, and community groups facilitated high engagement and smooth execution of the program. The WPD 2025 community engagement activity successfully enhanced public awareness of TB and demonstrated the vital role of pharmacists in health promotion. Continued multidisciplinary collaboration is recommended to strengthen community-based TB control efforts.
Co-Authors Fazri, Syifa Ainun Ike Yulia Wiendarlina Nhestricia, Nhadira Wawan Gunawan Yenni, Tengku