Background: The academic performance of nursing students in Nigeria has been hindered by ineffective teaching strategies, largely due to limited integration of innovative approaches in the teaching-learning process. Aim: This study investigated the regression analysis of nursing students perceive effectiveness of internet-based teaching-learning strategies on the teaching-learning process in North-central Nigeria. Method: A cross-sectional quantitative research design was adopted to assess the effectiveness of Internet-based teaching-learning strategies among nursing students across three institutions in North-central Nigeria. A total of 400 students were proportionately selected from a population of 1,267. Data were collected using a structured questionnaire, and analyzed using descriptive statistics and regression analysis to determine the relationship between Internet-based teaching-learning strategies and students’ academic performance. Results: Results showed that 73.5% of students testified that Internet-based teaching-learning strategies, with 79.5% indicating that these innovations made learning easier. Additionally, 73.3% of students believed that Internet-based teaching-learning strategies improved their overall academic performance. Significant proportion of students perceived mobile teaching-learning (69.8%), online game-based learning (72.5%), artificial intelligence (73.5%), and digital content platforms as effective tools for facilitating teaching-learning activities. Conclusion: This study concludes that regression coefficients for the entire four internets-based strategies are found to be significant with all the p-values < 0.05. This implies that there is a significant linear relationship in the effective use of internet-based teaching-learning and the academic performance of the students. Based on these findings, this study recommends that internet-based teaching-learning strategies should be prioritized to complement the traditional teaching approaches in nursing education. The necessary internet and technological facilities should be provided to support high-quality education.