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All Journal IJOEP : International Journal of Ecophysiology Jurnal EduHealth
Sri Tati Rukiyani
Institut Kesehatan Mitra Bunda
Agriculture, Biological Sciences & Forestry Health Professions Public Health Veterinary

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SOD2 Cell Guard from Free Radicals in Humans and Fruit Flies Rukiyani, Sri Tati
International Journal of Ecophysiology Vol. 7 No. 2 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i2.20752

Abstract

Superoxide dismutase 2 (SOD2) gene encodes the enzyme manganese superoxide dismutase (Mn-SOD) which plays a critical role in maintaining cellular redox homeostasis by dismuting superoxide radicals into hydrogen peroxide and oxygen. Localized in mitochondria, this enzyme protects mitochondrial DNA from oxidative damage caused by Reactive Oxygen Species (ROS), which can trigger mutations and carcinogenesis. The expression and activity of antioxidant enzymes such as SOD, catalase, and glutathione peroxidase are critical for ROS detoxification and genome stability. The human SOD2 gene, located on chromosome 6q25.3, consists of five exons and four introns, and encodes a homo-tetrameric protein with Mn³⁺ cofactor. Genetic variations, such as Val9Ala and Val16Ala polymorphisms, affect the structure of the mitochondrial targeting sequence and potentially increase susceptibility to various diseases. The SOD2 protein structure includes two functional domains containing residues essential for enzymatic activity, allowing the enzyme to perform its function in cellular defense against oxidative stress. Keywords: SOD2 , Mn-SOD, Reactive Oxygen Species , Mitochondria
Antibacterial Activity Test of Nipa Palm Leaf Extract (Nypa fruticans) Against Staphylococcus epidermidis Rury Trisa Utami; Sri tati Rukiyani
Jurnal EduHealth Vol. 17 No. 01 (2026): Jurnal EduHealt, January-March 2026
Publisher : Sean Institute

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Abstract

Skin disorders are a common health problem and can be caused by pathogenic bacterial infections. Staphylococcus epidermidis bacteria are known to play a role in various infections that can affect the skin surface. The use of natural ingredients as alternative antibacterial agents is crucial, one of which is nipah leaves (Nypa fruticans), which contain various secondary metabolites with potential antibacterial activity. This study aimed to determine the antibacterial activity of nipah leaf ethanol extract against two test bacteria and to determine the most effective concentration. Antibacterial testing used the disc diffusion method at concentrations of 200 μg/disc, 300 μg/disc, and 400 μg/disc, with chloramphenicol as a positive control and DMSO as a negative control. The results showed that nipah leaf extract formed a zone of inhibition at all tested concentrations. The largest zone of inhibition was found at a concentration of 400 μg/disc, measuring 8,2 mm against Staphylococcus epidermidis, which is classified as having medium inhibitory activity.
The Relationship between Thyroid Hormones and Hematological Parameters in Patients with Hyperthyroidism Sri Tati Rukiyani; Rury Trisa Utami; YANUARNI WULANDARI BAJI PAMAI; YULI MARIANY; IRBATH HAMDANIE
International Journal of Ecophysiology Vol. 8 No. 1 (2026): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v8i1.26062

Abstract

Hyperthyroidism is a condition characterized by increased production and secretion of thyroid hormones by the thyroid gland, commonly caused by Graves' disease and toxic multinodular goiter. Thyroid hormones play a crucial role in various physiological processes, including hematopoiesis in the bone marrow. Several studies have shown that thyroid hormones can directly and indirectly influence hematological parameters, potentially leading to anemia in patients. This study aimed to determine the relationship between T3, T4, fT3, fT4, and TSH hormones with hematological parameters in hyperthyroid patients. Data were obtained from 83 hyperthyroid patients at Dr. Cipto Mangunkusumo National General Hospital, Jakarta. Analysis used multiple linear regression and the chi-square test. The results showed a significant relationship between FT3 and MCHC, as well as between TSH, T3, T4, and FT4 with several hematological parameters, such as hemoglobin, hematocrit, erythrocytes, platelets, and MCV. However, no significant relationship was found with leukocyte count and MCH values.
Co-Authors IRBATH HAMDANIE Rury Trisa Utami YANUARNI WULANDARI BAJI PAMAI Yuli Mariany