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All Journal Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Hilyah Muthiah
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Health Professions Nursing Public Health

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Analisis Dosis dan Efek Neurofarmakologi Infusa Daun Tamarindus indica (L.) pada Hewan Uji Mencit Haryanto Haryanto; Sahrul Gunawan; Atiqah Ainunnisa' Andy Putri; Andi Eka Purwanti; Salsabila Ramadhani; Hilyah Muthiah; Saskiah Adiajuns; Sukma Febrianti sukri; Nur Aqila Novi Dwiyanti; Nurul Fazilawati Ode
Jurnal Ventilator Vol. 3 No. 4 (2025): Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v3i4.2135

Abstract

This study aims to investigate the effects of tamarind leaf extract (Tamarindus indica L.) on neuropharmacological activity in mice using calculated percentages of responses based on the parameters PSM, SSSP, DSSP, SL, RO, SM, PSL, and ANA. This research was conducted as a laboratory experiment using a completely randomized design (CRD) with three treatment concentrations: 1%, 2%, and 4%. Observations were performed to assess the percentage of activity produced by each sample concentration, followed by descriptive–quantitative analysis to determine the dose–response pattern. The results showed that tamarind leaf extract produced varying responses across concentrations. The SSSP, ANA, and RO effects demonstrated increased activity at the 2% concentration, whereas other parameters (PSM, PSL, SM, SL, and DSSP) showed decreased activity. Interestingly, the SSSP parameter exhibited a positive dose–response pattern with the highest activity of 55.84% at 2%. Overall, the effectiveness of tamarind leaf extract depends on the concentration level. The 2% concentration appears to be the optimal dose for several neuropharmacological effects, while the 4% concentration was most effective only for SSSP. These findings highlight the importance of multi-concentration testing to determine effective dosing of natural products for biological applications and the need for further investigation.
Co-Authors Andi Eka Purwanti Atiqah Ainunnisa' Andy Putri Haryanto Haryanto Nur Aqila Novi Dwiyanti Nurul Fazilawati Ode Sahrul Gunawan Salsabila Ramadhani Saskiah Adiajuns Sukma Febrianti sukri