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Abrar, Davin
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Potential Application of Bioactive Gambir Gum as a Next-Gen Oral Care Product: An In Vitro Study on Streptococcus mutans Reduction and Salivary pH Modulation Volasoohy, Navila Samsa; Azzuchri, M. Rofif; Mashfufah, Mutia Erliza; Abrar, Davin; Rosyadi, M. Zidan; Taufiqa, Zuhrah
International Journal of Health Engineering and Technology Vol. 4 No. 5 (2026): IJHESS JANUARY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i5.496

Abstract

Dental caries is the most prevalent oral health problem in Indonesia. Caries occurs due to bacterial colonization, primarily by Streptococcus mutans. Prevention of dental caries can be achieved by utilizing gambier (Uncaria gambier, Roxb) as an antimicrobial agent in the form of chewing gum combined with xylitol. This study aimed to develop an innovative bioactive formulation of gambier gum and to determine its effectiveness in reducing Streptococcus mutans colony counts and increasing salivary pH, both of which play roles in improving oral health and hygiene. This experimental study was conducted at the Biomedical Laboratory, Faculty of Medicine, Universitas Negeri Padang, from July to October 2025. Three formulations of gambier gum containing catechin concentrations of 0%, 70%, and 95% were tested for effectiveness by mixing them with participants’ saliva samples. The results showed a reduction in Streptococcus mutans colony counts compared to the control. Culture results of gambier gum with 0%, 70%, and 95% catechin demonstrated reductions of 40%, 60%, and 100%, respectively, relative to the control colonies. pH measurements indicated that gambier gum with 95% catechin prevented the saliva from becoming acidic. The gambier gum formulation containing 95% catechin exhibited the greatest antimicrobial effectiveness.
Co-Authors Azzuchri, M. Rofif Mashfufah, Mutia Erliza Rosyadi, M. Zidan Taufiqa, Zuhrah Volasoohy, Navila Samsa