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All Journal Oftalmologi: Jurnal Kesehatan Mata Indonesia
Irawan, Empi
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Education Health Professions Library & Information Science Medicine & Pharmacology Nursing

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Vitamin D Level in Adult Allergic Conjunctivitis Patients: A Systematic Review Putri, Maria Evane Navy Cahaya; Irawan, Empi
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 7 No 3 (2025): Oftalmologi: Jurnal Kesehatan Mata Indonesia
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v7i3.92

Abstract

Introduction: Allergic conjunctivitis is an immune-mediated ocular inflammation, and this study reviews evidence on the association between vitamin D levels and disease severity in adults. Methods: A systematic literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar for articles published between 2015 and 2025. Observational studies and clinical trials evaluating vitamin D status in adults with AC were included. Of 50 articles screened, four studies comprising 375 adult participants fulfilled the eligibility criteria. Extracted data included study design, vitamin D measurement methods, clinical outcomes, and statistical results. Risk of bias was assessed using ROBINS-I and Cochrane RoB 2.0, and the review followed PRISMA guidelines. Results: The included studies consisted of two observational studies and two clinical trials. Lower vitamin D levels were significantly associated with more severe AC symptoms in two observational studies. One clinical trial demonstrated mild symptomatic improvement following vitamin D supplementation, while another showed no significant effect. Variations in diagnostic criteria, laboratory methods, and confounding factors limited comparability. Conclusion: Lower vitamin D levels may enhance AC severity in adults. Further robust clinical trials are warranted to confirm these findings and to explore vitamin D supplementation's therapeutic role.
Co-Authors Putri, Maria Evane Navy Cahaya