<![CDATA[Acne vulgaris is a common inflammatory disorder that can affect psychological well-being in adolescents and young adults. This study aimed to examine the association between clinically confirmed acne vulgaris and self-confidence among undergraduate medical students. An analytical cross-sectional design was applied, involving 112 students from the Faculty of Medicine, Universitas Jenderal Achmad Yani, Class of 2023, recruited through consecutive sampling. Acne vulgaris was diagnosed clinically by a board-certified dermatologist, whereas self-confidence was assessed using the Ratnasari (2021) self-confidence questionnaire and the Rosenberg Self-Esteem Scale. Chi-square analysis was used to evaluate associations between acne status and self-confidence levels, with significance set at p < 0.05. Ethical approval was obtained from the Faculty of Medicine Ethics Committee (Approval No. 031/UM1.08/2024). Of the 112 respondents, 62 students (55.4%) were diagnosed with acne vulgaris. 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