<![CDATA[Dengue fever remains a major public health problem in Indonesia, particularly among children. Early recognition of clinical manifestations, supported by laboratory findings, is crucial for diagnosis, monitoring disease progression, and preventing severe complications. This study aimed to describe the clinical manifestations and laboratory findings of dengue fever cases in children. A cross-sectional study design was used, based on medical records of all pediatric patients aged 0–18 years who werediagnosed with dengue infection at Subang Regional Hospital from January to December 2024. Total sampling yielded 197 cases that met the inclusion criteria. Most patients were aged 6–18 years (73.1%) and male (57.4%). The highest incidence occurred in March (20.8%). The most common clinical manifestations were fever (100%), abdominal pain (61.9%), nausea (61.4%), vomiting (53.8%), and headache (37.1%). Warning signs were identified in 46.2% of patients, with persistent vomiting and abdominal pain being the most frequent. Laboratory findings showed thrombocytopenia (75.0%) and leukopenia (62.5%), particularly in the 6–18 age group, while anemia was most common in infants aged 0–1 year (92.3%). Serological examinations showed all patients were NS1 positive at initial testing, with IgM and IgG detected in subsequent examinations, indicating progression from the acute to the convalescent phase. These findings highlight the importance of integrated clinical and laboratory evaluation for early detection and appropriate management of dengue fever. DOI : 10.35990/amhs.v4n2.p77-86 REFERENCES Syamsir, Daramusseng A. Analisis spasial efektivitas fogging di wilayah kerja Puskesmas Makroman, Kota Samarinda. JNIK. 2018;1(2):1–7. Podung GCD, Tatura SNN, Mantik MFJ. Faktor risiko terjadinya sindroma syok dengue pada demam berdarah dengue. JBM. 2021;13(2):161–166. Ubaidillah, Kurniawan D. 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