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Hamijoyo , Laniyati
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Medicine & Pharmacology

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Factors Related to Infection in Systemic Lupus Erythematosus PatientsAdmitted to the Hospital Hamijoyo , Laniyati
Indonesian Journal of Rheumatology Vol. 14 No. 1 (2022): IJR VOL 14 No 1
Publisher : Indonesian Rheumatology Associantion

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Background: One of the causes of the increase in hospitalized SLE patientsis infection, and it is an important factor in morbidity and mortality, so it isnecessary to conduct a research to identify factors related to infection andthe type of infection caused in hospitalized SLE patients. Methods: Thisstudy is a retrospective, categorical descriptive study utilizing medicalrecords of SLE patients diagnosed with and treated for infection both onadmission and during their stay in Hasan Sadikin General Hospital betweenJanuary 2016 to June 2018. Results: Seventy- four patients were involvedinto this study. Female were 70 (94.6%), aged <40 years were 69 (93.2%)patients, and all 74 (100%) were entirely in an active disease condition witha mean Mexican systemic lupus erythematosus disease activity (MexSLEDAI) score of 9 ± 5.2. Fifty-three (71.6%) subjects experienced majorinfections. Mucocutaneous and kidney were the most organs involvementfound in SLE patients during infection, 63 (85.1%) and 57 (77.0%)respectively. Sixty-two (83.7%) subjects had received corticosteroids beforethe onset of infection, while pneumonia was the most common infectionfound in 33 patients (44.6%). This study also noted 12 (16.2%) patientsdeceased related to infection with most causes were respiratory failure(66.7%). Conclusion: Age less than 40-year-old, mucocutaneous and kidneyinvolvement and previously on corticosteroids were found higher among inhospitalized SLE patients. Most experienced major infections andpneumonia is the most common type of infection. 
B-Cell Activating Factor Profile and Quality of Life in Systemic LupusErythematosus Patients Hamijoyo , Laniyati
Indonesian Journal of Rheumatology Vol. 14 No. 2 (2022): IJR VOL 14 No 2
Publisher : Indonesian Rheumatology Associantion

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Background: B-Cell Activating Factor (BAFF) is a cytokine that plays a rolein systemic lupus erythematosus (SLE) pathogenesis.  BAFF increases B cellfunction, which will affect disease activity.  In addition to decreasing diseaseactivity, good quality of life (QoL) is one of the goals to be achieved in SLEtherapy, which is also affected by disease activity.  The purpose of this studyis to know the correlation of the BAFF profile with the QoL of SLE patients.Methods:  This was a cross-sectional study using secondary data from aprevious study.  The subjects of this study were SLE patients who had visitedthe rheumatology outpatient clinic or were hospitalized in Hasan SadikinHospital Bandung from September 2016 until February 2017.  Subjects wereasked to complete the Short Form-36 and measure their BAFF level inserum.  Demographic data were collected, and disease activity data wereassessed by Mexican Systemic Lupus Erythematosus Disease Activity Index(MEX-SLEDAI).  The statistical analysis used in this study was the Spearmantest. Results: There was a positive correlation between BAFF and MEXSLEDAI (r 0.238, p-value 0.038).  There was also a negative correlationbetween MEX-SLEDAI and PCS, as well as the MCS score (r -0.392 and 0.371, p-value <0.05). Conclusion:  BAFF levels will increase in higherdisease activity which will affect a poorer quality of life. 
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