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INTERAKSI FARMAKOGENOMIK DALAM POLIFARMASI OBAT ANTIHIPERTENSI DAN KAITANNYA DENGAN KOMPLIKASI INTRADIALISIS PADA PASIEN GAGAL GINJAL KRONIK DENGAN HEMODIALISA : PENDEKATAN SYSTEMATIC LITERATURE REVIEW Chairiati; Inge Maharani Ivo; Rahma Ziska
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 01 (2026): Volume 11 No. 01 Maret 2026 Published
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i01.41113

Abstract

This study aims to synthesize scientific evidence on pharmacogenomic interactions in antihypertensive polypharmacy and their association with intradialytic complications among chronic kidney disease (CKD) patients undergoing hemodialysis using a Systematic Literature Review (SLR) approach. A systematic literature search was conducted across PubMed, Scopus, Google Scholar, and Wiley Online Library for publications from 2017 to 2025, following the PRISMA guidelines and the PICO framework. A total of 30 articles met the inclusion criteria and were synthesized narratively. The findings indicate that antihypertensive polypharmacy is highly prevalent in the hemodialysis population, with an average use of ≥5–10 medications. The most frequently reported pharmacogenomic interactions involved phase I metabolic genes, particularly CYP2D6 and CYP2C9, influencing responses to beta-blockers and angiotensin receptor blockers (ARBs). Drug–drug–gene interactions in intensive polypharmacy conditions were associated with increased risks of intradialytic hypotension, intradialytic hypertension, bradycardia, electrolyte disturbances, and reduced quality of life. This synthesis highlights that intradialytic complications are influenced not only by drug class or dosing time but also by a combination of genetic factors, renal function, and medication burden. The integration of pharmacogenomic approaches, comprehensive polypharmacy evaluation, and clinical pharmacist involvement holds potential to improve patient safety and hemodynamic stability in hemodialysis patients.
PENGGUNAAN AMOKSISILIN PADA FARINGITIS AKUT PEDIATRIK DI PELAYANAN RAWAT JALAN : TINJAUAN SISTEMATIS TENTANG PENGGUNAAN RASIONAL DAN HASIL KLINIS Inge Maharani Ivo; Chairiati; Rahma Ziska
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 01 (2026): Volume 11 No. 01 Maret 2026 Public
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i01.41114

Abstract

This study aimed to systematically examine the patterns of use, rationality, and clinical outcomes of amoxicillin therapy in pediatric acute pharyngitis in outpatient settings. A Systematic Literature Review (SLR) was conducted in accordance with the PRISMA guidelines. Literature searches were performed in PubMed, Scopus, Google Scholar, and Wiley Online Library for English-language articles published between 2018 and 2025. Article selection was guided by the PICO framework and strict inclusion criteria, resulting in 30 studies that were analyzed using thematic narrative synthesis aligned with the three research questions. The review findings indicate that amoxicillin and amoxicillin–clavulanate predominate in the outpatient management of pediatric pharyngitis, frequently prescribed without adequate confirmation of bacterial etiology. The rationality of use remains suboptimal, as evidenced by inappropriate indications, wide variability in dosing regimens, and treatment durations that often exceed clinical guideline recommendations. In terms of clinical outcomes, amoxicillin was shown to be effective in appropriately diagnosed streptococcal pharyngitis, with no additional benefit of broad-spectrum antibiotics in symptom resolution, but with a lower risk of adverse effects. These findings underscore the importance of strengthening rational antibiotic use practices to improve patient safety and reduce antimicrobial resistance in the pediatric population
PENGGUNAAN AMOKSISILIN PADA FARINGITIS AKUT PEDIATRIK DI PELAYANAN RAWAT JALAN : TINJAUAN SISTEMATIS TENTANG PENGGUNAAN RASIONAL DAN HASIL KLINIS Inge Maharani Ivo; Chairiati; Rahma Ziska
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 01 (2026): Volume 11 No. 01, Maret 2026 Release
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i01.41567

Abstract

This study aimed to systematically examine the patterns of use, rationality, and clinical outcomes of amoxicillin therapy in pediatric acute pharyngitis in outpatient settings. A Systematic Literature Review (SLR) was conducted in accordance with the PRISMA guidelines. Literature searches were performed in PubMed, Scopus, Google Scholar, and Wiley Online Library for English-language articles published between 2018 and 2025. Article selection was guided by the PICO framework and strict inclusion criteria, resulting in 30 studies that were analyzed using thematic narrative synthesis aligned with the three research questions. The review findings indicate that amoxicillin and amoxicillin–clavulanate predominate in the outpatient management of pediatric pharyngitis, frequently prescribed without adequate confirmation of bacterial etiology. The rationality of use remains suboptimal, as evidenced by inappropriate indications, wide variability in dosing regimens, and treatment durations that often exceed clinical guideline recommendations. In terms of clinical outcomes, amoxicillin was shown to be effective in appropriately diagnosed streptococcal pharyngitis, with no additional benefit of broad-spectrum antibiotics in symptom resolution, but with a lower risk of adverse effects. These findings underscore the importance of strengthening rational antibiotic use practices to improve patient safety and reduce antimicrobial resistance in the pediatric population.
Co-Authors Inge Maharani Ivo Rahma Ziska