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Gede Febby Pratama Kusuma
Neurosurgery Sub-Department, Faculty of Medicine Universitas Udayana, Bali - Indonesia
Medicine & Pharmacology

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Recent Updates of Stem Cell Therapy in Spontaneous Intracerebral Haemorrhage Patients: A Review Article I Wayan Niryana; Ida Bagus Adiguna Wibawa; Gede Febby Pratama Kusuma
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.44046

Abstract

Background: Spontaneous intracerebral haemorrhage (sICH) is a severe neurological condition with high disability and mortality rates globally. Effective therapeutic strategies to overcome the acute and long-term problems caused by sICH are still lacking. Mesenchymal stem cell (MSCs) therapy with the neuroprotective and neuroregenerative properties has the potential to overcome the complex brain injury mechanisms caused by sICH.Objective: This review highlights the recent pre-clinical and clinical findings about MSCs therapy in sICH case and their mechanisms in promoting neurological recovery.Methods: This is a literature review study. Study reports available from various accredited database such as PubMed and Google Scholar are collected using the following keywords: ((“stroke” or “intracerebral haemorrhage”)) and (“stem cell”).Results: Pre-clinical studies proved that MSCs therapy can resolved the secondary brain insult caused by sICH and improved the brain functional and clinical status. The clinical studies proved that MSCs therapy are safe and well tolerated in human bodies. There were also beneficial MSCs therapy effects in sICH patients. However, the clinical studies results were still lacking and some were inconclusive.Conclusion: The preclinical studies of stem cell therapy in spontaneous intracerebral haemorrhage showed promising evidences and the potential of stem cell therapy for clinical use. However, the clinical studies were still lacking. Further clinical studies are needed to confirm the neuroprotective and neuroregenerative benefits of MSCs therapy from the pre-clinical studies.
SPONTANEOUS HIGH FLOW CAROTID-CAVERNOUS SINUS FISTULA CONFIRMED FROM DIGITAL SUBTRACTION ANGIOGRAPHY: A VERY RARE CASE I Wayan Niryana; Made Gemma Daniswara Maliawan; Gede Febby Pratama Kusuma; Dicky Teguh Prakoso; I Gusti Ngurah Dharma Kesuma
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 6 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i6.50683

Abstract

Background: Carotid cavernous fistula (CCFs) is characterized by an aberrant channel linking the carotid artery directly to the cavernous sinus. Most of the CCFs are classified as traumatic CCFs, which is occurred following trauma. Meanwhile spontaneous CCFs, which is occurred spontaneously, are very rare. Spontaneous CCFs typically occur in elderly women and are usually classified as low-flow, indirect fistulas of Barrow type D. This study aimed to present a rare case of a spontaneous high-flow CCFs classified as Barrow type A, due to its uncommon occurrence. Case presentation: A 56-years-old woman came fully alert presented with swelling and redness on the right eye since 1-month prior admission. Palpebral edema, episcleral injection, conjunctival chemosis, proptosis, and bruit were found from her right eye. CT-angiography found engorgement on the right cavernous sinus with superior ophthalmic vein (SOV) dilatation. The RICA DSA revealed that the contrast filled the cavernous sinus, SOV, facial vein, and internal jugular vein on the early artery phase, which indicates a high flow CCFs at the C4 with Barrow classification type A. The patient was planned for fistula embolization with coil. Conclusion: Spontaneous high flow CCFs is an extremely rare condition. Accurate history taking and thorough physical examination are essential to identify the classic triad of CCFs symptoms: proptosis, chemosis, and ocular bruit. The definitive diagnostic tool is a cerebral angiogram, which can reveal the presence of a fistula by demonstrating contrast filling of the cavernous sinus.
Co-Authors Dicky Teguh Prakoso I Gusti Ngurah Dharma Kesuma I Wayan Niryana I Wayan Niryana Ida Bagus Adiguna Wibawa Made Gemma Daniswara Maliawan