Winarto Winarto
Department of Microbiology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

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FACTORS INFLUENCING TREATMENT OUTCOMES OF DRUG-SENSITIVE TUBERCULOSIS PATIENTS: STUDY IN R.A. KARTINI HOSPITAL, JEPARA, INDONESIA Bambang Hariyana; Soeharyo Hadisaputro; Amin Husni; Winarto Winarto; Endang Mahati; Ari Budi Himawan
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 5 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i5.51448

Abstract

Introduction: Tuberculosis (TB) is an infectious and chronic disease with the highest mortality rate after ischemic heart disease and cerebrovascular disease. Indonesia has become the second-ranked worldwide for the highest estimated new TB cases. The TB treatment success rate (Treatment Success Rate/TSR) in Central Java Province stands at 87%, which is below the target of 90%. This study aims to provide an overview of the characteristics of TB patients at R.A. Kartini Hospital and the factors that influence the results of pulmonary TB therapy.Methods: This study is descriptive-analytical with a cross-sectional approach, using secondary data from the Tuberculosis Information System of R.A. Kartini Hospital from January 2023 to December 2023. Data were processed and analyzed using SPSS.Results: The average age of subjects was 39.26 ± 19.36, of which the majority were male (58.5%). Data showed that 58.1% of subjects had jobs, and the majority of subjects had no history of diabetes mellitus (DM) or human immunodeficiency virus (HIV) (86.6% and 96.7%, respectively). All subjects received tuberculosis (TB) treatment; most recovered (76.4%). Based on body mass index (BMI), 50.8% had a normal nutritional status. Chi-square test analysis showed a significant relationship between age and employment status with the success rate of TB treatment. However, the bivariate logistic regression analysis demonstrated that age was significantly related to TB treatment outcomes with an odds ratio (OR) of 1.033 (p = 0.000). Employment status revealed significant results; working subjects were 2.261 times more likely to experience suboptimal treatment outcomes (p = 0.013). Moreover, HIV history showed a significant relationship with TB treatment outcomes after adjusting for age with multivariate logistic regression analysis.Conclusion: Several factors were significantly related to TB treatment outcomes, such as age, employment status, and TB-HIV co-infection.