GeMa Cermat “DaGuSiBu” is a Ministry of Health program as an effort to increase awareness and change people's behavior towards correct drug use. The Drug Aware Family Movement (GKSO) launched by the Indonesian Pharmacists Association also uses the DaGuSiBu slogan to help and guide people in using medicines better. The "Ask Me Dagusibu" educational activity for the people of Girirejo Village, Kapanewon Imogiri, Bantul was carried out with the aim of providing knowledge about how to obtain, use, store and dispose of medicines correctly. The technical implementation of activities is carried out at one time, namely on September 17 2023. Evaluation of the effectiveness of activities is carried out by administering pretest and posttest questionnaires. A significant difference was obtained between participants' knowledge before and after giving the DaGuSiBu material which was indicated by a significance value of 0.001. The results of the activities showed that most of the participants in community service activities were dominated by female participants (76%). The majority of participants have an adult age range of 36-45 years (46%). High school education level (70%) and type of private employment (30%) were also the majority of characteristics of activity participants. The conclusion is that the majority of activity participants do not fully understand medicines, especially how to obtain, use, store and dispose of medicines correctly. Apart from that, activity participants were greatly helped by providing "ASK Me DaGuSiBu" education to increase knowledge and awareness of the importance of correct drug management.