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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical)
Andri Natanel
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Inhibitory Test of Scleria sumatrensis Stem Extract against Propionibacterium acnes Bacteria in Vitro Sonny D. Untu; Douglas N. Pareta; Selvana S. Tulandi; Jabes W. Kanter; Andri Natanel
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.505

Abstract

This study aims to test the antibacterial activity of Scleria sumatrensis extract against Propionibacterium acnes, a bacteria that causes acne. Extraction was carried out using the maceration method using 96% ethanol, and the antibacterial activity test was carried out using the diffusion method using a concentration of 100–500 ?g/disc. The results showed that the extract provided moderate antibacterial activity at a concentration of 100 ?g/disc and increased to strong at a concentration of 200–500 ?g/disc. S. sumatrensis extract contains secondary metabolite compounds such as phenolics, flavonoids, alkaloids, tannins, steroids, and terpenoids that play a role in inhibiting the growth of P. acnes through various mechanisms, including cell membrane damage, inhibition of protein synthesis, and disruption of bacterial metabolism. Based on the results of the study, S. sumatrensis extract has the potential as a natural antibacterial alternative for acne treatment without significant side effects or the risk of antibiotic resistance.
Co-Authors Douglas N. Pareta Jabes W. Kanter Selvana S. Tulandi Sonny D. Untu