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All Journal Journal of Innovative and Creativity
Tri Fadila Maharani
Faculty of Medicine, University of Alkhairaat, Indonesia
Education Languange, Linguistic, Communication & Media Mathematics Social Sciences Other

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Evaluation of Hematological and Biochemical Parameter Changes in MDR-TB Patients Undergoing OAT Treatment at RSUD Anutapura Palu in 2022-2025 indriani; Andi Meutia Ilhamjaya; Andrini Suryana Mangopa; Tri Fadila Maharani
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.484

Abstract

Multidrug-resistant tuberculosis (MDR-TB) is a major challenge in the control of tuberculosis in Indonesia. Long-term treatment with anti-tuberculosis drugs (OAT) is known to cause significant side effects on hematological and biochemical functions. This study aims to evaluate changes in leukocyte count, neutrophil-lymphocyte ratio (NLR), hematocrit, platelet count, hemoglobin, SGOT, SGPT, urea, and creatinine levels in MDR-TB patients undergoing OAT treatment at RSUD Anutapura Palu during the period of 2022-2024. The research employed a retrospective cohort design using secondary data from patient medical records. The results showed a decrease in leukocytes, NLR, platelets, and hemoglobin, as well as an increase in SGOT, SGPT, urea, creatinine and hematocrit after treatment. This study emphasizes the importance of regular monitoring for OAT side effects to improve treatment effectiveness and patient safety.
Co-Authors Andi Meutia Ilhamjaya Andrini Suryana Mangopa indriani