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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Pendidikan IPA (JPPIPA)
iche Azani
Universitas Muhammadiyah Pontianak
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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A Low-Barrier Approach to Developing Validated Chemistry Animations the Case of Chemical Bonding and Canva iche Azani; Hamdil Mukhlisin; Rizmanhardian Ashari Kurniawan
Jurnal Penelitian Pendidikan IPA Vol 11 No 9 (2025): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i9.12130

Abstract

Chemistry education still faces serious challenges in integrating three levels of representation, namely macroscopic, microscopic, and symbolic. This difficulty becomes more complex in abstract topics such as chemical bonding, which requires students to relate real phenomena to invisible molecular processes and formal chemical symbols. Conventional learning media tend to be static, making them less capable of depicting particle dynamics, which ultimately leads to conceptual misunderstandings. This study aims to develop and validate animation-based learning media as an innovative solution to bridge these limitations. The method used is Design-Based Research (DBR) with a 4D development model (Define, Design, Develop, Disseminate). The research subjects involved a panel of experts consisting of material, language, and media validators, as well as 35 tenth-grade students at MAN 3 Pontianak. The validation results showed a high level of reliability with Aiken scores of 93% (material), 91% (language), and 87% (media), respectively. The classroom feasibility test obtained an average score of 90%, which is classified as “very good.” Thus, the animated video developed using the Canva application proved to be effective, affordable, and provided a systematic framework that can be replicated to teach abstract chemistry concepts more comprehensively.
Metabolomics-Based Profiling of Antioxidant Compounds in Kesum (Polygonum minus) via UHPLC-Q-Orbitrap HRMS as Potential Anti-SARS-CoV-2 Candidates: An In Silico Approach Iche Azani; Dini Hadiarti; Arni Arni; Nur Aulia Fitri
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.%p

Abstract

Kesum or Polygonum minus (P. minus) is well-known for its high antioxidant content and potential as a therapeutic agent. This study aimed to identify active compounds in P. minus leaf extracts that serve as antioxidants and SARS-CoV-2 inhibitor candidates using metabolomics approach. P. minus leaves were extracted with ethanol and subsequently fractionated using n-hexane, ethyl acetate, and water. The ethyl acetate fraction exhibited the highest antioxidant activity as measured by the DPPH method. Further analysis using UHPLC-Q-Orbitrap HRMS identified several compounds, including 3-hydroxybenzoic acid, quercetin-3betha-D-glucoside, tectoridin, apigenin, hispidulin, and (±)-usnic acid. These compounds were subsequently evaluated in silico by molecular docking against the 1OG5 and 7CMD target proteins. The results demonstrated strong interactions between these compounds and the protein active sites, supporting their potential as both antioxidants and inhibitors of SARS-CoV-2. This study suggests that P. minus is a promising source of bioactive compounds for development in herbal-based therapies in West Kalimantan.
Co-Authors Arni Arni Dini Hadiarti Hamdil Mukhlisin Nur Aulia Fitri Rizmanhardian Ashari Kurniawan