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All Journal Sehat Rakyat: Jurnal Kesehatan Masyarakat Indonesian Health Issue
Galih Muchlis Hermawan
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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TAK-003 Dengue Vaccine Efficacy and Safety: A Systematic Literature Review Using PRISMA Galih Muchlis Hermawan; Syuharul Qomar; Iga Putri Imansari
Indonesian Health Issue Vol. 5 No. 1 (2026): FEBRUARY
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/inhis.v5i1.164

Abstract

Background: Dengue is a global public health problem with a high disease burden in both endemic and non-endemic regions. Although dengue vaccines have been developed, evidence regarding the efficacy and safety of the TAK-003 vaccine remains fragmented, with variations across serotypes, age groups, baseline serostatus, and study designs. Objective: This study aims to analyze and synthesize scientific evidence on the efficacy and safety of the tetravalent dengue vaccine TAK-003 based on clinical trial data and real-world evidence. Methods: A Systematic Literature Review was conducted in January 2025 in accordance with PRISMA guidelines. Literature searches were performed in the ScienceDirect, PubMed, ProQuest, and ClinicalKey databases, yielding a total of 1,011 initial records. After duplicate removal, title and abstract screening, and full-text eligibility assessment, studies were included if they: (1) explicitly investigated TAK-003, (2) reported outcomes related to efficacy, immunogenicity, and/or safety, (3) employed clinical trial, observational, or post-marketing surveillance designs, and (4) were available as full-text articles in English. Non-empirical studies, animal studies, commentaries, and narrative reviews were excluded. Results: Five high-quality articles from Scopus Q1 journals met the inclusion criteria. The thematic analysis identified five main themes: the safety and immunogenicity of TAK-003 when co-administered with other vaccines, manufacturing consistency with stable immune responses, long-term effectiveness in preventing dengue infection and hospitalization for up to 4.5 years, tetravalent protection against all four dengue serotypes, and a favorable safety profile based on post-marketing data, with most adverse events being mild. Conclusion: The TAK-003 vaccine demonstrates favorable efficacy and safety profiles in both clinical trials and real-world settings. Although variability in effectiveness across serotypes and age groups persists, the available evidence supports TAK-003 as a promising strategy for dengue prevention.
Epidemiological Analysis of Environmental and Behavioral Risk Factors for Typhoid Fever Occurrence: A Case-Control Study at RSU PKU Muhammadiyah Delanggu, Klaten Galih Muchlis Hermawan; Vita Susianawati; Firman Adhitya
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v5i1.7098

Abstract

This study aimed to analyze risk factors associated with the occurrence of typhoid fever at RSU PKU Muhammadiyah Delanggu, Klaten. The study employed a quantitative design with a case-control approach, involving 48 respondents consisting of 24 typhoid fever cases and 24 non-typhoid fever controls with a 1:1 ratio. The research instrument was a questionnaire covering respondent characteristics, personal hygiene, eating habits outside the home, and level of knowledge. Data analysis was conducted using univariate and bivariate analyses with the Odds Ratio (OR) test and a 95% Confidence Interval (CI). The results showed that gender was not significantly associated with the occurrence of typhoid fever (OR = 1.18; 95% CI: 0.38-3.66). Poor personal hygiene (OR = 11.40; 95% CI: 2.96-43.80), frequent eating outside the home (OR = 15.00; 95% CI: 3.64-61.90), and low level of knowledge (OR = 7.29; 95% CI: 2.04-26.10) were proven to be significant risk factors for typhoid fever. Therefore, promotive and preventive interventions focusing on hygienic behavior, food safety, and improvement of public knowledge are necessary to reduce the incidence of typhoid fever.
Co-Authors Firman Adhitya Iga Putri Imansari Syuharul Qomar Vita Susianawati