Website design and optimization decisions are often driven by subjective opinions, internal organizational preferences, or prevailing industry trends rather than empirical evidence derived from large-scale user interaction data, resulting in suboptimal performance and inconsistent user experiences. In digital environments characterized by high data volume and velocity, the absence of a structured experimentation methodology limits organizations’ ability to effectively leverage Big Data for continuous website improvement. This paper presents a comprehensive and systematic methodological guide to A or B testing as a data-driven approach for enhancing website effectiveness in data-intensive contexts. Unlike existing A or B testing guides that focus mainly on tools or isolated experimental outcomes, this study proposes an end-to-end framework integrating hypothesis formulation, scalable experimental design, statistical rigor, iterative learning, and practical decision-making into a unified and replicable process. The methodology outlines the complete A or B testing lifecycle, including alignment of business objectives with measurable data signals, development of testable hypotheses, controlled experiment implementation, large-scale data collection, and statistical analysis to ensure validity and significance of findings. The results demonstrate that a disciplined and continuous A or B testing program supported by Big Data analytics enables incremental yet compounding improvements in website performance. Through illustrative case examples, the study shows that relatively small, data-informed changes to website elements such as headlines, calls-to-action, images, and layout structures can lead to statistically significant gains in conversion rates, user engagement, and overall user experience. The paper concludes that A or B testing serves as a strategic Big Data analytics mechanism that supports evidence-based website optimization decisions grounded in empirical user behavior rather than intuition.