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Pratiwi Ratih Halimatus Sya'diah
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Biochemistry, Genetics & Molecular Biology Chemistry Mathematics Physics

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Evaluation of Microplastic Content in Human Circulatory System and Its Potential Impacts on Systemic Health Kun Mardiwati Rahayu; Mila Sari; Pratiwi Ratih Halimatus Sya'diah
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.357

Abstract

Given the escalating global production of plastics and the absence of regulatory frameworks addressing internal human exposure, microplastic contamination has emerged as an urgent environmental and public health policy concern.Using micro Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy, MPs were detected in 76.0% of samples collected from 50 healthy adults, with an average concentration of 3.15 ± 1.25 particles/mL and a mean particle size of 5.8 ± 2.1 μm. Polyethylene terephthalate (PET) and polypropylene (PP) were the dominant polymer types, while fragments and fibers represented the most common morphologies. Correlation analyses revealed significant positive associations between total MP concentration and inflammatory biomarkers C-reactive protein (r = +0.415, p = 0.003) and interleukin-6 (r = +0.288, p = 0.043) as well as oxidative stress marker malondialdehyde (r = +0.350, p = 0.013), suggesting that MPs may contribute to subclinical systemic inflammation and oxidative imbalance. These findings provide empirical evidence supporting the systemic circulation of MPs and their potential role as low-grade biological stressors that could influence vascular homeostasis. Further longitudinal and mechanistic studies are warranted to elucidate causal pathways, characterize nanoplastic fractions, and establish standardized analytical protocols. This research underscores the growing necessity to treat microplastic exposure as a critical environmental and public health issue.
Discovery of Active Bacterial Microbiome in Human Brain Tissue: Implications for Neurodegenerative Diseases and Depression Pratiwi Ratih Halimatus Sya'diah; Eka Cahya Muliawati
Science Journal Get Press Vol 1 No 1 (2024): January, 2024
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v1i1.449

Abstract

The concept of a sterile human brain has recently been challenged by emerging evidence suggesting the presence of microbial DNA and components within brain tissue. This study aimed to investigate the presence and disease-specific patterns of microbial signatures in human brains affected by Alzheimer’s disease and depression, compared to healthy controls. Using 16S rRNA sequencing on post-mortem brain samples, we detected microbial DNA in all groups, with notable differences in diversity and composition. Alzheimer’s brains exhibited reduced microbial richness and were enriched in genera such as Cutibacterium and Streptococcus, which may contribute to neuroinflammation and amyloid aggregation. Depressive brains showed increased abundance of Eggerthella, potentially influencing neurotransmitter metabolism and systemic inflammatory pathways, while control brains had higher prevalence of Lactobacillus and Bifidobacterium, consistent with neuroprotective roles. These findings support the emerging “brain microbiome” concept and suggest that low-abundance microbial communities may reflect disease-associated processes or interactions via the microbiota-gut-brain axis. While causality and microbial viability remain to be established, the study highlights the potential relevance of brain-associated microbes in neurodegenerative and psychiatric disorders and provides a foundation for future experimental and translational research exploring microbiome-targeted diagnostic and therapeutic strategies.
Co-Authors Eka Cahya Muliawati Kun Mardiwati Rahayu Mila Sari