The development of social media opens new opportunities for innovation in learning, particularly in chemistry subjects. Instagram, as one of the most popular platforms, holds great potential to be used as a learning medium because it is easily accessible and capable of presenting engaging visual content. The small-scale chemistry (SSC) ethnoscience-based practicum approach is considered effective in overcoming the limitations of school laboratory facilities by using fewer chemicals, being cost-efficient, safe, and environmentally friendly. The voltaic cell, as one of the electrochemistry topics, is still often perceived as difficult for students to understand if taught only theoretically, thus requiring more practical and relevant learning media. This study aims to analyze the need for integrating Instagram into small-scale chemistry practicum on the topic of voltaic cells. The method employed was a descriptive survey by distributing questionnaires to students and chemistry teachers in several senior high schools in Kepanjen Regency. The results indicate that students found Instagram helpful for discussions and independent learning, while teachers considered SSC effective in reducing challenges related to costs, waste, and limited facilities. The majority of respondents supported the development of SSC-based learning media integrated with Instagram to improve students’ understanding of the voltaic cell concept.