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Yulia Azzahra
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Nursing Public Health

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Studi in Silico Seskuiterpen Hidrokarbon dari Resin Daemonorops Draco sebagai Kandidat Agen Antikanker Nerdy N; Nilsya F. Zebua; Adelia Puspita R.N; Titi K. Hulu; Yulia Azzahra; Azzahra T.M. Simatupang; Nikasia G. Sitohang; Chindy T. Manullang
Jurnal Kesehatan Amanah Vol. 10 No. 1 (2026): Mei: Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v10i1.1062

Abstract

Daemonorops draco is a rattan plant that produces resin traditionally used as medicine and is known to contain various bioactive compounds. Previous GC–MS analysis identified 42 active compounds in the resin of Daemonorops draco, including a group of sesquiterpene hydrocarbons suspected to contribute to its biological activities. This study aimed to evaluate the potential of six sesquiterpene hydrocarbons, namely α-cubebene, α-copaene, α-amorphene, δ-cadinene, aromadendrene, and viridiflorene, as anticancer candidates using an in silico approach. PASS Online prediction indicated that all compounds exhibit antineoplastic and apoptosis agonist activities with relatively high probability of activity (Pa) values and low probability of inactivity (Pi) values, particularly α-copaene, α-amorphene, and α-cubebene. Toxicity evaluation using ProTox 3.0 classified all compounds into Toxicity Class V with high LD₅₀ values, indicating low acute toxicity. ADMET analysis using pkCSM demonstrated favorable pharmacokinetic and safety profiles without major toxicity indications. Overall, sesquiterpene hydrocarbons from Daemonorops draco show potential as anticancer agents based on computational predictions.
Co-Authors Adelia Puspita R.N Azzahra T.M. Simatupang Chindy T. Manullang Nerdy N Nikasia G. Sitohang Nilsya F. Zebua Titi K. Hulu