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All Journal Borneo Journal Of Pharmascientech Journal of Pharmaceutical and Sciences.
Rahmawati , Ismi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Aktivitas Antibakteri Kombucha Daun Sirsak (Anonna muricata L.) Terhadap Bakteri Escherichia coli Rahmasari, Nadia; Rahmawati , Ismi; Saptarini , Opstaria
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.996

Abstract

Infectious diseases caused by pathogenic bacteria such as Escherichia coli are increasing, especially due to antibiotic resistance. One potential alternative treatment is the use of natural antibacterial compounds, such as those found in soursop leaves (Annona muricata L.). Soursop leaves contain various bioactive compounds, such as flavonoid polyphenols, acetogenins, and tannins, which have antibacterial activity. This study aims to of soursop leaf-based probiotic kombucha fermentation in inhibiting the growth of Escherichia coli. In this study, probiotic kombucha was produced through a fermentation process using Symbiotic Culture of Bacteria and Yeast (SCOBY) with variations in temperature, time, and soursop leaf extract concentration parameters. Activity testing was carried out using the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) methods to assess its antibacterial effectiveness. The results showed that soursop leaf kombucha fermentation had significant antibacterial activity against Escherichia coli. The disc diffusion activity test obtained in this study was 9.1 mm (15% concentration); 5.10 mm (10% concentration); and 2.3 mm (5% concentration) with different concentration variations on the 7th day of fermentation. The resulting inhibition zone diameter for E. coli bacteria indicates that kombucha's antibacterial activity is in the moderate category, as it produced the highest inhibition zone of 9.1 mm. This study demonstrates that soursop leaf kombucha has the potential to be developed as a functional probiotic beverage with effective and natural antibacterial effects.
Analisis Efektivitas-Biaya Antihipertensi Amlodipin Dibandingkan Candesartan Pada Pasien Stroke Iskemik Rawat Jalan di Rumah Sakit Surakarta Lestari, Rizkia Putri; Andayani , Tri Murti; Rahmawati , Ismi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.768

Abstract

Hypertension is one of the risk factor for ischemic stroke. Amlodipin and Candesartan are hypertensive therapies in stroke patients. The use of antihypertensive drugs requires long-term treatment, so it is necessary to conduct a cost-effectiveness analysis to determine effective and efficient use of drugs. The purpose of this study is to find out the most cost-saving antihypertensive at Hospital Surakarta. The study was conducted retrospectively on outpatient ischemic stroke patients at the Surakarta Regional General Hospital for the periode 2023-2024. Sample number data used was 114 on ischemic stroke patients according to the inclusion criteria. Effectiveness is seen from the patient's blood pressure reaching the target and the cost is calculated from the provider's perspective, including direct medical costs. CEA is calculated based on the value of ACER and ICER. The results showed the effectiveness of Amlodipin 66,10% and Candesartan 54,55%. The average total cost of Amlodipin is Rp. 556,129 ± 208,187 and Rp. 620,436 ± 232,382 for Candesartan. The value of ACER for amlodipine was Rp. 8,413.44, while candesartan is Rp. 11,377.32. The calculation of the ICER value obtained a negative result Rp. 5,584. The results of the cost-effectiveness analysis showed that amlodipin is a cost-saving antihypertensive for outpatient ischemic stroke patients.
Co-Authors Andayani , Tri Murti Lestari, Rizkia Putri Rahmasari, Nadia Saptarini , Opstaria