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All Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Nurmeilis
Department of Pharmacy, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Jl.Kertamukti No.5 Ciputat, South Tangerang Banten 15419, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Study of Potential Drug Interactions in COVID-19 Patients with Comorbid Type 2 Diabetes Mellitus at The General Hospital in South Tangerang City, Period 2021ral Hospital in South Tangerang City Nurmeilis; Yusroh Umami; Nurhaida; Delila Eliza
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.39167

Abstract

Diabetes mellitus is one of the common comorbidities found in COVID-19 patients. The use of large amounts of medication (polypharmacy) in COVID-19 patients with comorbid diabetes mellitus can increase the possibility of drug interactions. The study aimed to determine the potential drug-drug interactions and it is the relationship with clinical outcomes in COVID-19 patients with comorbid type 2 diabetes mellitus at the General Hospital in South Tangerang City. The study was a retrospective study conducted in the hospital by using patients medical records from January-December 2021. Potential drug-drug interactions were analyzed by using the software, Medscape, and Drugs.com. The 97 patients met the inclusion and exclusion criteria. The results of the study were found in 40 patients who experience drug interactions with COVID-19 drugs and antidiabetics (58.2%), the majority of them are in moderate severity degree (78.5%), major severity degree (21.5%), with pharmacodynamic mechanism (100%). There is no significant relationship between drug interactions and clinical outcomes of patients (P>0.05). The interactions found were all pharmacodynamic, although there was no significant relationship to clinical outcomes, therapeutic monitoring was still required.
Co-Authors Delila Eliza Nurhaida Yusroh Umami